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Preoperative anemia and postoperative outcomes in immediate breast reconstructive surgery : a critical analysis of 10,958 patients from the ACS-NSQIP database
(Plastic and reconstructive surgery. Global open., 2013-08-06)
Background: Preoperative anemia is independently associated with adverse
outcomes after general and cardiac surgery. Outcomes after breast reconstruction
are not established. We assessed the effect of preoperative ...
Positive effect of neurolysis on diabetic patients with compressed nerves of the lower extremities: a systematic review and meta-analysis
(American Society of Plastic Surgeons, 2013-07-02)
BACKGROUND:
Despite proven benefits of upper extremity nerve decompression in diabetics, neurolysis for diabetic patients with lower extremity (LE) nerve compression remains controversial.
METHODS:
A search of ...
Use of case reports and the Adverse Event Reporting System in systematic reviews: overcoming barriers to assess the link between Crohn's disease medications and hepatosplenic T-cell lymphoma
(BioMed Central, 2013-07-05)
BACKGROUND:
To identify demographic and clinical characteristics associated with cases of hepatosplenic T-cell lymphoma (HSTCL) in patients with Crohn's disease, and to assess strength of evidence for a causal relationship ...
Increased flap weight and decreased perforator number predict fat necrosis in DIEP breast reconstruction
(American Society of Plastic Surgeons, 2013-05-28)
BACKGROUND: Compromised perfusion in autologous breast reconstruction results in fat necrosis and flap loss. Increased flap weight with fewer perforator vessels may exacerbate imbalances in flap perfusion. We studied deep ...
Patient-reported assessment of functional gait outcomes following superior gluteal artery perforator reconstruction
(American Society of Plastic Surgeons, 2013-08-14)
BACKGROUND:
Harvesting the superior gluteal artery perforator (SGAP) flap involves dissection of vessels through the gluteal muscle, potentially compromising gait and ambulation. We compared patient-reported gait and ...
LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction
(Nature Publishing Group, 2013-01-18)
Cells continuously sense and respond to external mechanical forces through their cytoskeleton. Here we show that only a small subset of actin fibers, those forming the perinuclear actin cap that wraps around the nucleus, ...
Time-varying wing-twist improves aerodynamic efficiency of forward flight in butterflies
(PLoS Organization, 2013-01-16)
Insect wings can undergo significant chordwise (camber) as well as spanwise (twist) deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads ...
Differences in Reporting of Analyses in Internal Company Documents Versus Published Trial Reports: Comparisons in Industry-Sponsored Trials in Off-Label Uses of Gabapentin
(PLoS Organization, 2013-01-29)
BACKGROUND:
Details about the type of analysis (e.g., intent to treat [ITT]) and definitions (i.e., criteria for including participants in the analysis) are necessary for interpreting a clinical trial's findings. Our ...
Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.
(PLoS Organization, 2013-06-21)
Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in development and in pathological conditions such as cancer, retinopathy and ischemic diseases. However, no detailed mass-action ...
Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA
(BioMed Central, 2013-03-22)
BACKGROUND:
The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined ...