Now showing items 1-3 of 3
HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks
(PLoS Organization, 2012-11-15)
BACKGROUND: Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood. The ...
Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA
(BioMed Central, 2013-03-22)
BACKGROUND: The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined ...
Expression of VEGF and semaphorin genes define subgroups of triple negative breast cancer.
(PLoS Organizaton, 2013-05-08)
Triple negative breast cancers (TNBC) are difficult to treat due to a lack of targets and heterogeneity. Inhibition of angiogenesis is a promising therapeutic strategy, but has had limited effectiveness so far in breast ...