Browsing 2012/2013 Recipients by Issue Date
Now showing items 1-20 of 36
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Basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome
(Oxford University Press, 2012-06-29)MacroH2A is a histone H2A variant that is typically found in heterochromatic regions of the genome. A positively charged linker that connects the histone-fold with the macro-domain was suggested to have DNA-binding ... -
Improving teaching on an inpatient pediatrics service: a retrospective analysis of a program change
(BioMed Central, 2012-10-01)Background: The traditional role of the faculty inpatient attending providing clinical care and effectively teaching residents and medical students is threatened by increasing documentation requirements, pressures to ... -
All-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging
(OpticsInfoBase, 2012-10-12)We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery ... -
Antepartum depression and anxiety associated with disability in African women : cross-sectional results from the CDS Study in Ghana and Cote d’Ivoire
(PLoS Organization, 2012-10-22)Background: Common mental disorders, particularly unipolar depressive disorders, rank among the top 5 with respect to the global burden of disease. As a major public health concern, antepartum depression and anxiety not ... -
Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence.
(Nature Publishing Group, 2012-11-14)EGFR is the best studied receptor tyrosine kinase. Yet, a comprehensive mechanistic understanding of EGFR signaling is lacking, despite very active research in the field. In this paper, we investigate the role of the ... -
HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks
(PLoS Organization, 2012-11-15)BACKGROUND: Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remain poorly understood. The ... -
Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy
(Dove Press, 2012-11-18)Despite recent advances in neonatal care and monitoring, asphyxia globally accounts for 23% of the 4 million annual deaths of newborns, and leads to hypoxic-ischemic encephalopathy (HIE). Occurring in five of 1000 live-born ... -
ECG marker of adverse electrical remodeling post-myocardial infarction predicts outcomes in MADIT II study
(PLoS Organization, 2012-12-14)Background Post-myocardial infarction (MI) structural remodeling is characterized by left ventricular dilatation, fibrosis, and hypertrophy of the non-infarcted myocardium. Objective The goal of our study was ... -
Decoupling nucleosome recognition from DNA binding dramatically alters the properties of the Chd1 chromatin remodeler
(Oxford University Press, 2012-12-28)Chromatin remodelers can either organize or disrupt nucleosomal arrays, yet the mechanisms specifying these opposing actions are not clear. Here, we show that the outcome of nucleosome sliding by Chd1 changes dramatically ... -
Time-varying wing-twist improves aerodynamic efficiency of forward flight in butterflies
(PLoS Organization, 2013-01-16)Insect wings can undergo significant chordwise (camber) as well as spanwise (twist) deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads ... -
LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction
(Nature Publishing Group, 2013-01-18)Cells continuously sense and respond to external mechanical forces through their cytoskeleton. Here we show that only a small subset of actin fibers, those forming the perinuclear actin cap that wraps around the nucleus, ... -
Differences in Reporting of Analyses in Internal Company Documents Versus Published Trial Reports: Comparisons in Industry-Sponsored Trials in Off-Label Uses of Gabapentin
(PLoS Organization, 2013-01-29)BACKGROUND: Details about the type of analysis (e.g., intent to treat [ITT]) and definitions (i.e., criteria for including participants in the analysis) are necessary for interpreting a clinical trial's findings. Our ... -
Multiple Consequences of a Single Amino Acid Pathogenic RTK Mutation: The A391E Mutation in FGFR3
(PLoS Organization, 2013-02-20)The A391E mutation in fibroblast growth factor receptor 3 (FGFR3) is the genetic cause for Crouzon syndrome with Acanthosis Nigricans. Here we investigate the effect of this mutation on FGFR3 activation in HEK 293 T cells ... -
Comparison of Sum Absolute QRST Integral, and Temporal Variability in Depolarization and Vectorcardiography Approach, in Healthy Men and Women
(PLoS Organization, 2013-02-22)BACKGROUND: Recently we showed the predictive value of sum absolute QRST integral (SAI QRST) and repolarization lability for risk stratification of sudden cardiac death (SCD) in heart failure patients. The goal of this ... -
Clinical study reports of randomised controlled trials: an exploratory review of previously confidential industry reports
(BMJ Publishing Group, 2013-02-26)OBJECTIVE: To explore the structure and content of a non-random sample of clinical study reports (CSRs) to guide clinicians and systematic reviewers. SEARCH STRATEGY: We searched public sources and lodged Freedom ... -
Pulmonary Tuberculosis Incidence and Risk Factors in Rural Areas of China: A Cohort Study
(PLoS Organization, 2013-03-12)The incidence of tuberculosis (TB) and its risk factors in China remains unclear. This study examined TB incidence and relative risk factors in rural areas of China. Participants (n = 177,529) were recruited in Xiangtan ... -
Titles versus titles and abstracts for initial screening of articles for systematic reviews
(Dove Medical Press, 2013-03-15)BACKGROUND: There is no consensus on whether screening titles alone or titles and abstracts together is the preferable strategy for inclusion of articles in a systematic review. METHODS: TWO METHODS OF SCREENING ... -
Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA
(BioMed Central, 2013-03-22)BACKGROUND: The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined ... -
Role of exhaled nitric oxide as a predictor of atopy.
(BioMed Central, 2013-05-02)BACKGROUND: The fractional exhaled nitric oxide (FeNO) is a quantitative, noninvasive and safe measure of airways inflammation that may complement the assessment of asthma. Elevations of FeNO have recently been found ... -
Expression of VEGF and semaphorin genes define subgroups of triple negative breast cancer.
(PLoS Organizaton, 2013-05-08)Triple negative breast cancers (TNBC) are difficult to treat due to a lack of targets and heterogeneity. Inhibition of angiogenesis is a promising therapeutic strategy, but has had limited effectiveness so far in breast ...