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dc.contributor.authorMavadia, Jessica
dc.contributor.authorXi, Jiefeng
dc.contributor.authorChen, Yongping
dc.contributor.authorXingde, Li1
dc.date.accessioned2014-03-28T14:02:03Z
dc.date.available2014-03-28T14:02:03Z
dc.date.issued2012-10-12
dc.identifier.citationdoi: 10.1364/BOE.3.002851en_US
dc.identifier.issn2156-7085
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/36715
dc.descriptionPMC3493218en_US
dc.description.abstractWe present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery of OCT source and fluorescence excitation light while collecting the backscattered OCT signal through the single-mode core and fluorescence emission through the large inner cladding of the DCF. Circumferential beam scanning was performed by rotating a 45° reflector using a miniature DC motor at the distal end of the endoscope. Additionally, a custom DCF coupler and a wavelength division multiplexer (WDM) were utilized to seamlessly integrate both imaging modalities to achieve an entirely fiber-optically based dual-modality imaging system. We demonstrated simultaneous intraluminal 3D OCT and 2D (surface) fluorescence imaging in ex vivo rabbit esophagus using the dual-modal endomicroscopy system. Structural morphologies (provided by OCT) and fluorophore distribution (provided by the fluorescence module) could be clearly visualized, suggesting the potential of the dual-modality system for future in vivo and clinical applications.en_US
dc.description.sponsorshipJH Libraries Open Access Funden_US
dc.language.isoen_USen_US
dc.publisherOpticsInfoBaseen_US
dc.relation.ispartofseriesBiomedical Optics Express;v. 3 no. 11 pp. 2851–2859 2012
dc.subjectSpectroscopyen_US
dc.subjectfluorescence and luminescenceen_US
dc.subjectEndoscopic imagingen_US
dc.subjectOptical coherence tomographyen_US
dc.titleAll-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imagingen_US
dc.title.alternativeAll fiber optic endoscopy platform for simultaneous OCT and fluorescence imagingen_US
dc.typeArticleen_US


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