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dc.contributor.authorXi, Jiefeng
dc.contributor.authorChen, Yongping
dc.contributor.authorLi, Xingde
dc.date.accessioned2014-04-02T12:01:25Z
dc.date.available2014-04-02T12:01:25Z
dc.date.issued2013-05-09
dc.identifier.citationdoi: 10.1364/BOE.4.000842en_US
dc.identifier.issn2156-7085
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/36727
dc.descriptionPMC3675864en_US
dc.description.abstractWe report a cross-referencing method to quickly and accurately characterize the optical properties of nanoparticles including the extinction, scattering, absorption and backscattering cross sections by using an OCT system alone. Among other applications, such a method is particularly useful for developing nanoparticle-based OCT imaging contrast agents. The method involves comparing two depth-dependent OCT intensity signals collected from two samples (with one having and the other not having the nanoparticles), to extract the extinction and backscattering coefficient, from which the absorption coefficient can be further deduced (with the help of the established scattering theories for predicting the ratio of the backscattering to total scattering cross section). The method has been experimentally validated using test nanoparticles and was then applied to characterizing gold nanocages. With the aid of this method, we were able to successfully synthesize scattering dominant gold nanocages for the first time and demonstrated the highest contrast enhancement ever achieved by the gold nanocages (and by any nanoparticles of a similar size and concentration) in an in vivo mouse tumor model. This method also enables quantitative analysis of contrast enhancement and provides a general guideline on choosing the optimal concentration and optical properties for the nanoparticle-based OCT contrast agents.en_US
dc.description.sponsorshipJH Libraries Open Access Funden_US
dc.language.isoen_USen_US
dc.publisherOptical Society of Americaen_US
dc.relation.ispartofseriesBiomedical optics express;v. 4 no. 6 p. 842 - 51
dc.subjectOptical coherence tomographyen_US
dc.subjectMedical and biological imagingen_US
dc.subjectScatteringen_US
dc.subjectScattering measurementsen_US
dc.titleCharacterizing optical properties of nano contrast agents by using cross-referencing OCT imaging.en_US
dc.typeArticleen_US


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