Show simple item record

dc.contributor.authorGuduru, Abhilash
dc.contributor.authorLansdown, Jason
dc.contributor.authorChernichenko, Daniil
dc.contributor.authorBerger, Ronald D.
dc.contributor.authorTereshchenko, Larisa G.
dc.date.accessioned2014-04-04T15:08:32Z
dc.date.available2014-04-04T15:08:32Z
dc.date.issued2013-08-12
dc.identifier.citationdoi: 10.3389/fphys.2013.00208en_US
dc.identifier.issn1664-042X
dc.identifier.urihttp://jhir.library.jhu.edu/handle/1774.2/36744
dc.descriptionPMC3740232en_US
dc.description.abstractBackground: While it is known that elevated baseline intracardiac repolarization lability is associated with the risk of fast ventricular tachycardia (FVT)/ventricular fibrillation (VF), the effect of its longitudinal changes on the risk of FVT/VF is unknown. Methods and Results: Near-field (NF) right ventricular (RV) intracardiac electrograms (EGMs) were recorded every 3-6 months at rest in 248 patients with structural heart disease [mean age 61.2 ± 13.3; 185(75%) male; 162(65.3%) ischemic cardiomyopathy] and implanted cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) [201 (81%) primary prevention]. Intracardiac beat-to-beat QT variability index (QTVINF) was measured on NF RV EGM. During the first study phase (median 18 months), participants made on average 2.4 visits. Then remote follow-up was continued for an additional median period of 3 years. Average QTVINF did not change during the first year after ICD implantation (-0.342 ± 0.603 at baseline vs. -0.262 ± 0.552 at 6 months vs. -0.334 ± 0.603 at 12 months); however, it decreased thereafter (-0.510 ± 0.603 at 18 months; P = 0.042). Adjusted population-averaged GEE model showed that the odds of developing FVT/VF increased by 75% for each 1 unit increase in QTVINF. (OR 1.75 [95%CI 1.05-2.92]; P = 0.031). However, individual patient-specific QTVINF trends (increasing, decreasing, flat) varied from patient to patient. For a given patient, the odds of developing FVT/VF were not associated with increasing or decreasing QTVINF over time [OR 1.27; (95%CI 0.05-30.10); P = 0.881]. Conclusion: While on average the odds of FVT/VF increased with an increase in QTVINF, patient-specific longitudinal trends in QTVINF did not affect the odds of FVT/VF.en_US
dc.description.sponsorshipJH Libraries Open Access Funden_US
dc.language.isoen_USen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.ispartofseriesFrontiers in physiology;v. 4 p. 208
dc.subjectVentricular tachyarrhythmiaen_US
dc.subjectRepolarization labilityen_US
dc.subjectLongitudinal analysisen_US
dc.subjectIntracardiac electrogramsen_US
dc.subjectQT variability indexen_US
dc.titleLongitudinal changes in intracardiac repolarization lability in patients with implantable cardioverter-defibrillator.en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record