SPECIFIC DNA SEQUENCE RESPONISIVE DNA CROSSLINKED HYDROGEL AND ITS APPLICATIONS
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In the first theme of the thesis, we show hydrogel architectures photopatterned by DNA co-polymer that can be actuated by up to three different DNA sequence. The hydrogel architectures show great shape change accurately at the region we design after the specific biomolecular signal is applied to the system. This combination of microfabrication technology with DNA nanotechnology allow us to build tiny soft devices or soft robots that can be actuated by particular DNA sequence. The second theme of this thesis is generating DNA crosslinked microgel through microfluidic methods. To apply the method, we first form emulsion droplets iii out of microfluidic device then solidify the droplets by subsequent UV triggered polymerization. In this droplets generating process, by tuning the flow rate of the continuous phase and the dispersed phase, microfluidic generation of droplets can be well controlled over size and monodispersity. With this strategy, we can generate a great amount of microgels with uniform spherical geometry in a relatively simpler process and a faster speed than microfabrication and template particle synthesis.