ACTIVITY PATTERNS IN A PARKINSON'S MONKEY MODEL
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In a study conducted at the University of Pittsburgh, 35 female rhesus monkeys were exposed to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an effort to establish a plausible animal model for Parkinson's disease progression and treatment using neurotrophic factors. In addition to standard clinical measurements of Parkinson's severity, actigraphy devices recording minute level activity were t to each of the monkeys. This thesis primarily aims to understand how activity patterns in healthy subjects can predict their susceptibility to developing Parkinson's-like symptoms as a result of MPTP exposure. Secondarily, we show how subjects respond to neurotrophic factors in terms of both subjects' activity and through standard clinical metrics.