Browsing Theses and Dissertations, Electronic (ETDs) by Title
Now showing items 2354-2373 of 6070
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Galectin-3 and the Modulation of Antitumor Immunity
(Johns Hopkins UniversityUSA, 2020-03-25)In the last decade, galectin-3 has emerged as an important player in the development and progression of cancer, favoring immune suppression and dysfunction at disease sites. While this protein is a known tumor-promoting ... -
Gamers, Hunters, Provocateurs: Digital Mediations of Violence, Gender and Faith in the Arab World
(Johns Hopkins UniversityUSA, 2015-01-26)My dissertation examines how digital media and communications technologies shape responses to gendered violence, human security, and women’s rights in the Middle East. I combine discourse analysis with a material investigation ... -
GASTROINTESTINAL SYMPTOMS AND THE GUT IN AUTISM SPECTRUM DISORDERS: BURDEN, MEASUREMENT, AND ETIOLOGIC RELEVANCE
(Johns Hopkins UniversityUSA, 2019-06-14)Background: Individuals with ASD are more likely to experience gastrointestinal symptoms (GI). The goal of this dissertation was to shed light on the burden GI symptoms place on individuals with ASD and their families, ... -
The Gaussian Isoperimetric Problem and the Self-Shrinkers of Mean Curvature Flow
(Johns Hopkins University, 2014-07-06)We record work done by the author joint with John Ross [27] on stable smooth solutions to the gaussian isoperimetric problem, and we also record work done by the author [26] on two-dimensional self-shrinkers of any ... -
GDE2-dependent activation of canonical Wnt signaling in neurons regulates oligodendrocyte maturation
(Johns Hopkins UniversityUSA, 2020-05-18)Neurons and oligodendrocytes communicate to regulate oligodendrocyte development and to ensure appropriate axonal myelination. Here, we show that Glycerophosphodiesterase phosphodiesterase 2 (GDE2) is part of a signaling ... -
GDE3 Function in Oligodendrocyte Precursor Cell Proliferation
(Johns Hopkins UniversityUSA, 2018-11-12)Oligodendrocyte specification, proliferation and differentiation are tightly controlled by extrinsic signals; however, proteins that modulate cellular response to these factors remain unclear. Six-transmembrane GDEs are ... -
GEL-FORMING EYE DROPS FOR ENHANCED INTRAOCULAR PRESSURE LOWERING FOR TREATMENT OF GLAUCOMA
(Johns Hopkins UniversityUSA, 2020-05-05)Glaucoma is one of the leading causes of blindness worldwide. Glaucoma develops as a result of an imbalance in aqueous humor production and drainage in the anterior chamber. Obstruction or blockage in the trabecular meshwork ... -
Gemcitabine Sensitivity on Podocalyxin Knockdown Pancreatic Cell Line SW1990
(Johns Hopkins University, 2014-12-01)In this study, we tested cell survival following treatments of Gemcitabine (GE) in scrambled control and Podocalyxin (PODXL) knockdown pancreatic cancer cell line SW1990. After testing several major chemotherapeutic drugs ... -
Gender Affirmation Therapy as Accommodation: Transitioning in a Nonideal Society Based on an Informed Consent Model
(Johns Hopkins UniversityUSA, 2021-08-11)Trans people who seek out Gender Affirming Therapies have historically met various barriers as they have gone through the process of transitioning. From restrictive diagnoses to unversed medical practitioners to misunderstandings ... -
Gender Differences in Depressive Symptoms in Kumasi, Ghana
(Johns Hopkins UniversityUSA, 2013-09-02)Background: Depression is an important public health issue globally, and accounts for an increasingly large proportion of disease burden in low-income countries. Depression is twice as common in women as men. Despite the ... -
Gender, Tyranny, and Republicanism in England, 1603-1660
(Johns Hopkins UniversityUSA, 2014-08-26)This dissertation examines how classical history and gendered conceptions of masculine governance and misgovernance shaped the political culture of seventeenth-century England, the distinctive character of English republican ... -
Gender-Affirming Surgery: A Visual Resource for Patients, Relatives, and Healthcare Providers
(Johns Hopkins UniversityUSA, 2018-03-22)Gender dysphoria occurs when an individual’s psychological identity as a male or female conflicts with their biological sexual characteristics, resulting in anxiety, depression, and distress. Transgender individuals often ... -
Gender-Based Violence and HIV Risk among Female Sex Workers in Iringa, Tanzania: Implications for a Community Empowerment Response
(Johns Hopkins UniversityUSA, 2017-06-12)Globally, female sex workers (FSWs) bear a disproportionate burden of GBV and HIV. Prior work has demonstrated how substance use overlaps with GBV and HIV to further increase FSWs’ risk for negative health outcomes. This ... -
Gendered Sexual Health among Men in India
(Johns Hopkins UniversityUSA, 2017-03-09)Background: The term “men who have sex with men” (MSM) provokes the illusion of sexual risk homogeneity among male sexual minorities. The term overemphasizes a single aspect of sex between men (behavior) and overlooks ... -
Gendering the Work of Debt Collection: Women, Law, and the Credit Economy in New England, 1730-1790
(Johns Hopkins UniversityUSA, 2015-10-06)“Gendering the Work of Debt Collection” analyzes women, gender, and the credit-based economies of New England’s largest Atlantic ports, Boston and Newport, and their hinterlands between 1730 and 1790. Examining women’s ... -
Gene Discovery and Glutamate Signaling Defects in Intellectual Disability and Autism
(Johns Hopkins University, 2015-03-24)Neurodevelopmental disorders are a common class of brain disorders that affect up to 1 in 6 children in the industrialized world. They include a range of diseases, including Attention Deficit Hyperactivity Disorder, Autism ... -
GENE DISCOVERY FOR RARE MENDELIAN DISEASES: DISORDERS OF THE TTT COMPLEX AND DISORDERS PRESENTING AS VERY EARLY ONSET INFLAMMATORY BOWEL DISORDERS
(Johns Hopkins UniversityUSA, 2017-11-22)Gene discovery for Mendelian disorders has witnessed tremendous advances with the development of whole exome sequencing technology and in vitro disease modeling methods in patient-derived cells and mouse models. As part ... -
GENE EXPRESSION ANALYSIS IN MEASLES VIRUS RESEARCH
(Johns Hopkins University, 2007-03-26)The sequencing of the human genome ushered in the era of high-throughput biology. Rapid, whole cell analysis is replacing the molecular reductionist approach of the last century. Microarrays are one of the main high-throughput ... -
Gene Expression Analysis of Cellular Changes in Response to Fibroblast Injection and Wounding
(Johns Hopkins UniversityUSA, 2021-04-15)Within the United States, there are over two million individuals who have undergone amputations with an additional 185,000 receiving amputations each year (Yang et al., 2012). Amongst the amputee population, 48.2% of ... -
GENE EXPRESSION IN RETINAL DEVELOPMENT, DEGENERATION, AND DIFFERENTIATION
(Johns Hopkins UniversityUSA, 2017-05-23)RNA-seq is a next generation sequencing based method for transcriptome wide characterization of gene expression. This dissertation explores the application of RNA-seq, both at the level of the tissue and at the level of ...