Browsing Theses and Dissertations, Electronic (ETDs) by Title
Now showing items 838-857 of 2173
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Gamers, Hunters, Provocateurs: Digital Mediations of Violence, Gender and Faith in the Arab World
(Johns Hopkins UniversityUSA, 2015-01-26)My dissertation examines how digital media and communications technologies shape responses to gendered violence, human security, and women’s rights in the Middle East. I combine discourse analysis with a material investigation ... -
The Gaussian Isoperimetric Problem and the Self-Shrinkers of Mean Curvature Flow
(2014-07-06)We record work done by the author joint with John Ross [27] on stable smooth solutions to the gaussian isoperimetric problem, and we also record work done by the author [26] on two-dimensional self-shrinkers of any ... -
Gemcitabine Sensitivity on Podocalyxin Knockdown Pancreatic Cell Line SW1990
(2014-12-01)In this study, we tested cell survival following treatments of Gemcitabine (GE) in scrambled control and Podocalyxin (PODXL) knockdown pancreatic cancer cell line SW1990. After testing several major chemotherapeutic drugs ... -
Gender Differences in Depressive Symptoms in Kumasi, Ghana
(Johns Hopkins UniversityUSA, 2013-09-02)Background: Depression is an important public health issue globally, and accounts for an increasingly large proportion of disease burden in low-income countries. Depression is twice as common in women as men. Despite the ... -
Gender-Based Violence and HIV Risk among Female Sex Workers in Iringa, Tanzania: Implications for a Community Empowerment Response
(Johns Hopkins UniversityUSA, 2017-06-12)Globally, female sex workers (FSWs) bear a disproportionate burden of GBV and HIV. Prior work has demonstrated how substance use overlaps with GBV and HIV to further increase FSWs’ risk for negative health outcomes. This ... -
Gene Discovery and Glutamate Signaling Defects in Intellectual Disability and Autism
(2015-03-24)Neurodevelopmental disorders are a common class of brain disorders that affect up to 1 in 6 children in the industrialized world. They include a range of diseases, including Attention Deficit Hyperactivity Disorder, Autism ... -
GENE EXPRESSION ANALYSIS IN MEASLES VIRUS RESEARCH
(2007-03-26)The sequencing of the human genome ushered in the era of high-throughput biology. Rapid, whole cell analysis is replacing the molecular reductionist approach of the last century. Microarrays are one of the main high-throughput ... -
GENE EXPRESSION PROFILING IN ISCHEMIC AND NONISCHEMIC CARDIOMYOPATHY
(2006-08-03)Background Despite our growing understanding of the pathophysiology and management of heart failure, there exist no strategies to individualize therapy using predictors of long-term prognosis and response to therapy. ... -
General and Specific Receptor Tyrosine Kinase Signaling Mechanisms Revealed by Analysis of Chimeric EGFR and IR Family Receptors
(Johns Hopkins UniversityUSA, 2015-07-14)Receptors embedded in the plasma membrane serve to relay signals from the outside to the inside of the cell and regulate cell growth and differentiation. Disruption of these signals can occur by mutation or abnormal ... -
Generalizability of randomized controlled trials of substance use disorder treatments
(Johns Hopkins UniversityUSA, 2017-05-23)Randomized controlled trials (RCTs) are widely considered the gold standard to assess the effectiveness of new treatments. Decisions for clinical guidelines and health policies are often made based on findings of RCTs. ... -
Generalizations, extensions and applications for principal component analysis
(Johns Hopkins UniversityUSA, 2016-02-24)Principal component analysis (PCA) is one of the most important dimension reduction technique. It is widely used in many applications including economics, finance and medical research. In this research, several novel ... -
Generation and Reactivity of Bio-Inspired Heme-Peroxo-Copper Model Complexes
(Johns Hopkins UniversityUSA, 2017-08-17)A major theme across many fields of science is the goal of understanding how structure begets function. This dissertation explores such relationships utilizing synthetic inorganic and coordination chemistry to interrogate ... -
Genetic Disruption of Ki-67 Results in Decreased Clonogenic Proliferation
(2014-03-19)Two well-known hallmarks of cancer are the abilities to sustain proliferation and invade surrounding tissue, and pathways involved in these processes have been scrutinized for possible therapeutic targets in recent years. ... -
Genetic Diversity of Rickettsia parkeri in sympatric tick populations at a focal site in northern Virginia: Implications for pathogen dispersal and spotted fever group rickettsiosis.
(2015-04-22)Rickettsia parkeri is emerging as a tick-borne pathogen of public health importance, particularly for its previously unrecognized role as a potential pathogen responsible for rapidly increasing cases of spotted fever group ... -
Genetic Testing Preferences and Intentions in Patients with Clinically Diagnosed Familial Hypercholesterolemia
(Johns Hopkins UniversityUSA, 2017-12-18)Purpose Familial Hypercholesterolemia (FH) is a common (1/250) Mendelian disorders that results in elevated LDL cholesterol levels from birth, and if left untreated can result in premature heart disease. Only up to 10% of ... -
Genetically Encoded Calcium Indicator Illuminates Calcium Dynamics In Primary Cilia
(2014-04-21)The primary cilium is an extraordinary, hair-like structure that extends outward from the plasma membrane of cells. Ubiquitous to almost every cell type in the human body, this singular, immotile structure, serves as an ... -
Genetics and mechanisms of telomere-mediated lung disease
(Johns Hopkins UniversityUSA, 2017-01-04)Chronic lung disease is the third leading cause of death in the United States. Emphysema and pulmonary fibrosis are two of the most common forms and are thought in part to represent a premature aging phenotype in the lung. ... -
Genetics Researchers’ Perceived Obligations to Return Incidental Findings and Individual Research Results to Participants
(2015-01-30)Background: Clinical investigators are increasingly facing decisions about returning individual research results (IRRs) and incidental findings (IFs) from genome sequencing to research participants. Studies have shown that ... -
Genocide: A Political Genealogy
(Johns Hopkins UniversityUSA, 2015-07-01)The Polish jurist Raphael Lemkin added the concept of genocide to our vocabulary barely seventy years ago. In the ensuing decades, ‘genocide’ has become a highly politicized term employed in discussions of ethics, law, and ... -
GENOME-WIDE STUDIES ON POST-TRANSCRIPTIONAL REGULATION
(Johns Hopkins UniversityUSA, 2016-06-08)Regulation of gene expression is essential for cellular survival and complex responses or phenotypes. Improvements in sequencing technology enable investigation of RNA transcription as a means to understand complex biological ...