Browsing Theses and Dissertations, Electronic (ETDs) by Title
Now showing items 1608-1627 of 3713
-
IDENTIFICATION AND ANALYSIS OF GOLGI TRANSPORTERS THAT PROVIDE HOMEOSTASIS FOR GLYCOSYLATION AND OTHER GOLGI PROCESSES
(Johns Hopkins UniversityUSA, 2018-10-23)The Golgi apparatus of eukaryotes is a critical organizing center that is responsible for protein and lipid maturation, sorting, and trafficking. Because of the diverse population of proteins and lipids being modified at ... -
Identification and Applications of Llama-Derived Single Domain Antibodies Binding to Glycoprotein D of Herpes Simplex Virus 2
(Johns Hopkins University, 2013-12-06)There are currently no protective vaccines or microbicides that can prevent the transmission of herpes simplex virus 2 (HSV-2). The purpose of this thesis was to develop a microbicide based on a llama-derived single domain ... -
Identification and Characterization of a Stem Cell-Like Population in Ovarian Cancer
(Johns Hopkins University, 2014-01-31)Eighty percent of patients with advanced ovarian cancer show an initial clinical response to therapy, but seventy-five percent of these patients eventually relapse. This transient clinical response would be consistent ... -
Identification and Characterization of Histone H3 Lysine 23 Methylation in Germline Chromatin
(Johns Hopkins UniversityUSA, 2014-02-28)Eukaryotic DNA and histone proteins are packaged into chromatin that can occur in two cytologically distinct states: heterochromatin, which is highly compacted and transcriptionally repressive; or euchromatin, which is ... -
Identification and characterization of novel factors needed for two aspects of Myxococcus xanthus physiology: social motility and osmoregulation
(Johns Hopkins University, 2013-11-07)Myxococcus xanthus is a non-pathogenic Gram-negative, delta proteobacterium. This bacterium has become an important model system for the study of complex bacterial phenomena such as cell-to-cell communication, motility, ... -
IDENTIFICATION AND ELUCIDATION OF MIR-214 AND MIR-29A AS POTENT REGULATORS OF LIVER FIBROSIS
(Johns Hopkins University, 2013-12-13)Liver fibrosis is the accumulation of extracellular matrix proteins in response to hepatocellular injury. Worldwide, liver fibrosis and cirrhosis accounts for nearly 160,000 deaths per year. It results from many different ... -
Identification of a Global Aneuploidy-Associated Transcriptional and Phenotypic Signature in Budding Yeast
(Johns Hopkins UniversityUSA, 2017-05-02)Aneuploidy, an unbalanced genome state with either gain or loss of chromosomes, is known to have dramatic effects on cellular physiology, ranging from detrimental effects including genetic disorders such as Down Syndrome ... -
Identification of a role for B7-H4 in neutrophil homeostasis and innate immunity
(Johns Hopkins University, 2014-03-27)B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T cell responses. To explore physiological roles of B7-H4, we created B7-H4-deficient (KO) mice by genetic targeting. B7-H4KO mice are healthy ... -
Identification of an inhibitory domain in RAG-2 that gates access of the V(D)J recombinase to chromatin
(Johns Hopkins UniversityUSA, 2017-03-22)V(D)J recombination is initiated by a specialized transposase consisting of the subunits RAG-1 and RAG-2. The susceptibility of gene segments to DNA cleavage by the V(D)J recombinase is correlated with epigenetic modifications ... -
IDENTIFICATION OF INCOMPLETE INFORMATION GAMES WITH MULTIPLE EQUILIBRIA AND UNOBSERVED HETEROGENEITY
(Johns Hopkins UniversityUSA, 2014-06-11)This dissertation mainly studies identification of finite action games with incomplete information. The essential contribution of this dissertation is to allow for the presence of multiple equilibria and/or unobserved ... -
Identification of Non-Traditional Molecular Contributors to Cystic Fibrosis
(Johns Hopkins UniversityUSA, 2016-06-14)Next generation sequencing has enabled the identification of patients with unambiguous recessive Mendelian phenotypes and incomplete genotypes, meaning zero or only one disease-causing mutation are detected by diagnostic ... -
IDENTIFICATION OF NOVEL GANGLIOSIDE-ASSOCIATED PROTEINS AND ADVANCES IN SINGLE-CELL GANGLIOSIDE METABOLOMICS IN NERVE CELLS
(Johns Hopkins UniversityUSA, 2013-09-23)Gangliosides, glycosphingolipids that carry at least one sialic acid residue, are enriched in the plasma membranes of neurons. Despite their abundance, little is known about the molecules they interact with in the plasma ... -
IDENTIFICATION OF NOVEL NATURALLY OCCURRING GENETIC INTERACTIONS USING INTER-PERSON VARIATION AND VIRUS DYNAMICS IN HEPATITIS C VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS.
(Johns Hopkins UniversityUSA, 2015-08-14)Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are two chronic viral infections of humans for which no vaccine exists. considerable research effort has focused on in vitro, ex vivo, and animal models due ... -
IDENTIFICATION OF PANCREATIC CANCER-SPECIFIC ANTIGENS USING A NOVEL QUANTITATIVE SEROPROTEOMICS APPROACH
(Johns Hopkins UniversityUSA, 2014-03-19)Pancreatic ductal adenocarcinoma (PDA) is among the most deadly cancers with less than 5% of the patients living beyond 5 years after diagnosis. Lack of early diagnostic biomarkers and resistance to current therapies help ... -
IDENTIFICATION OF SOURCES OF POLLUTANTS IN BALTIMORE HARBOR
(Johns Hopkins University, 2014-05-09)Nutrient and sediment pollution are important issues in Baltimore Harbor. The poor water quality has affected human activities and lives in the Harbor. This report applied Chesapeake Bay Phase 5.3 Watershed Model output ... -
Identification of T cell derived KLK1b22 as a novel regulator of systemic metabolism
(Johns Hopkins UniversityUSA, 2018-03-28)In an effort to understand the role of mTORC1 in regulating T cell differentiation, we generated mice in which Rheb is selectively deleted in T cells (T-Rheb -/- mice). During the course of these studies we noted that the ... -
Identification of telomere length regulators by pooled library screening
(Johns Hopkins UniversityUSA, 2017-01-19)Telomeres protect chromosome ends from damage (d'Adda di Fagagna et al., 2003). In the presence of telomerase, telomere length is maintained at an established equilibrium (Greider, 1996). Alterations to this equilibrium ... -
Identification of the Roles of the Small Ubiquitin-Related Modifier (SUMO) in Cellular Stress Response
(Johns Hopkins University, 2015-04-10)Proper protein folding is essential for cell function, as misfolding leads to cell stress and cytotoxicity. Misfolded proteins are associated with several serious diseases in humans such as Parkinson’s and Alzheimer’s ... -
IDENTIFICATION OF U6 PROMOTERS FOR CRISPR-CAS9 GENOME ENGINEERING IN AEDES AEGYPTI
(Johns Hopkins UniversityUSA, 2018-04-25)Aedes aegypti is the primary vector of Zika and Dengue viruses. The objective of this study was to identify a functional U6 snRNA promoter for plasmid-based sgRNA expression and CRISPR-Cas9 genome engineering in Ae. aegypti. ... -
IDENTIFYING AND CORRECTING COGNITIVE BIASES IN SUBJECTIVE PROBABILITY ELICITATION SURVEYS: MODEL BASED APPROACHES
(Johns Hopkins UniversityUSA, 2016-02-22)As probability elicitation becomes widely used, methods other than one-on-one interviews are being used to elicit expert probabilities. This thesis considers biases that may arise when probabilities are elicited in an ...