Browsing Theses and Dissertations, Electronic (ETDs) by Title
Now showing items 2645-2664 of 6070
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I mean what you see: the role of first person sensory experience in shaping the cognitive and neural bases of concepts
(Johns Hopkins UniversityUSA, 2019-11-20)In my dissertation, I inquire into the origin of knowledge through the lens of blindness – which has served as a window into this question since Locke’s famous claim that a blind person could never entertain ideas of vision. ... -
IDENTIFICATION AND ANALYSIS OF GOLGI TRANSPORTERS THAT PROVIDE HOMEOSTASIS FOR GLYCOSYLATION AND OTHER GOLGI PROCESSES
(Johns Hopkins UniversityUSA, 2018-10-23)The Golgi apparatus of eukaryotes is a critical organizing center that is responsible for protein and lipid maturation, sorting, and trafficking. Because of the diverse population of proteins and lipids being modified at ... -
Identification and Applications of Llama-Derived Single Domain Antibodies Binding to Glycoprotein D of Herpes Simplex Virus 2
(Johns Hopkins University, 2013-12-06)There are currently no protective vaccines or microbicides that can prevent the transmission of herpes simplex virus 2 (HSV-2). The purpose of this thesis was to develop a microbicide based on a llama-derived single domain ... -
Identification and Characterization of a Stem Cell-Like Population in Ovarian Cancer
(Johns Hopkins University, 2014-01-31)Eighty percent of patients with advanced ovarian cancer show an initial clinical response to therapy, but seventy-five percent of these patients eventually relapse. This transient clinical response would be consistent ... -
Identification and Characterization of Histone H3 Lysine 23 Methylation in Germline Chromatin
(Johns Hopkins UniversityUSA, 2014-02-28)Eukaryotic DNA and histone proteins are packaged into chromatin that can occur in two cytologically distinct states: heterochromatin, which is highly compacted and transcriptionally repressive; or euchromatin, which is ... -
Identification and characterization of novel factors needed for two aspects of Myxococcus xanthus physiology: social motility and osmoregulation
(Johns Hopkins University, 2013-11-07)Myxococcus xanthus is a non-pathogenic Gram-negative, delta proteobacterium. This bacterium has become an important model system for the study of complex bacterial phenomena such as cell-to-cell communication, motility, ... -
Identification and comparison of imputed and genotyped variants for genome-wide association study of orofacial cleft case-parent trios
(Johns Hopkins UniversityUSA, 2019-04-26)Background: Orofacial clefts (OFCs) – cleft lip with/without cleft palate (CL/P) and cleft palate (CP) – are the most common craniofacial malformations among newborns. Both CL/P and CP show strong familial aggregation ... -
IDENTIFICATION AND ELUCIDATION OF MIR-214 AND MIR-29A AS POTENT REGULATORS OF LIVER FIBROSIS
(Johns Hopkins University, 2013-12-13)Liver fibrosis is the accumulation of extracellular matrix proteins in response to hepatocellular injury. Worldwide, liver fibrosis and cirrhosis accounts for nearly 160,000 deaths per year. It results from many different ... -
Identification of a Global Aneuploidy-Associated Transcriptional and Phenotypic Signature in Budding Yeast
(Johns Hopkins UniversityUSA, 2017-05-02)Aneuploidy, an unbalanced genome state with either gain or loss of chromosomes, is known to have dramatic effects on cellular physiology, ranging from detrimental effects including genetic disorders such as Down Syndrome ... -
Identification of a role for B7-H4 in neutrophil homeostasis and innate immunity
(Johns Hopkins University, 2014-03-27)B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T cell responses. To explore physiological roles of B7-H4, we created B7-H4-deficient (KO) mice by genetic targeting. B7-H4KO mice are healthy ... -
Identification of an inhibitory domain in RAG-2 that gates access of the V(D)J recombinase to chromatin
(Johns Hopkins UniversityUSA, 2017-03-22)V(D)J recombination is initiated by a specialized transposase consisting of the subunits RAG-1 and RAG-2. The susceptibility of gene segments to DNA cleavage by the V(D)J recombinase is correlated with epigenetic modifications ... -
Identification of biomarkers and modifiable risk factors for Parkinson's disease dementia
(Johns Hopkins UniversityUSA, 2019-04-05)Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and afflicts approximately 1% of individuals over age 65. The dementia that develops in association with PD is devastating to both the ... -
IDENTIFICATION OF INCOMPLETE INFORMATION GAMES WITH MULTIPLE EQUILIBRIA AND UNOBSERVED HETEROGENEITY
(Johns Hopkins UniversityUSA, 2014-06-11)This dissertation mainly studies identification of finite action games with incomplete information. The essential contribution of this dissertation is to allow for the presence of multiple equilibria and/or unobserved ... -
IDENTIFICATION OF INPUTS FOR A QUANTITATIVE MICROBIAL RISK ASSESSMENT OF VIBRIO PARAHAEMOLYTICUS IN CHESAPEAKE BAY AND WASHINGTON STATE
(Johns Hopkins UniversityUSA, 2019-04-23)Background / Introduction: Non-cholera Vibrio bacteria are a major cause of foodborne illness in the United States. Raw oyster consumption is increasingly implicated in gastroenteritis caused by pathogenic strains of ... -
IDENTIFICATION OF IRREVERSIBLE INHIBITORS OF DNA POLYMERASE B
(Johns Hopkins UniversityUSA, 2020-12-23)Many chemotherapeutics induce cell death by attacking deoxyribonucleic acid (DNA). Unfortunately, many cancer drugs suffer from poor selectivity and high toxicity. In addition to poor selectivity, the cytotoxic effects of ... -
Identification of Non-Traditional Molecular Contributors to Cystic Fibrosis
(Johns Hopkins UniversityUSA, 2016-06-14)Next generation sequencing has enabled the identification of patients with unambiguous recessive Mendelian phenotypes and incomplete genotypes, meaning zero or only one disease-causing mutation are detected by diagnostic ... -
IDENTIFICATION OF NOVEL GANGLIOSIDE-ASSOCIATED PROTEINS AND ADVANCES IN SINGLE-CELL GANGLIOSIDE METABOLOMICS IN NERVE CELLS
(Johns Hopkins UniversityUSA, 2013-09-23)Gangliosides, glycosphingolipids that carry at least one sialic acid residue, are enriched in the plasma membranes of neurons. Despite their abundance, little is known about the molecules they interact with in the plasma ... -
IDENTIFICATION OF NOVEL NATURALLY OCCURRING GENETIC INTERACTIONS USING INTER-PERSON VARIATION AND VIRUS DYNAMICS IN HEPATITIS C VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS.
(Johns Hopkins UniversityUSA, 2015-08-14)Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are two chronic viral infections of humans for which no vaccine exists. considerable research effort has focused on in vitro, ex vivo, and animal models due ... -
IDENTIFICATION OF PANCREATIC CANCER-SPECIFIC ANTIGENS USING A NOVEL QUANTITATIVE SEROPROTEOMICS APPROACH
(Johns Hopkins UniversityUSA, 2014-03-19)Pancreatic ductal adenocarcinoma (PDA) is among the most deadly cancers with less than 5% of the patients living beyond 5 years after diagnosis. Lack of early diagnostic biomarkers and resistance to current therapies help ... -
IDENTIFICATION OF PRIMARY TIME DRIVERS IN COMPLIANCE FOR NON-MEDICAL STEM RESEARCH, AND BEST PRACTICES FOR REDUCING TIME INVESTMENT BY FACULTY
(Johns Hopkins UniversityUSA, 2019-08-05)An increase in time commitment for compliance measures in STEM research has been measured by the 2018 Federal Demonstration Partnership Survey (Schneider, 2019), despite widespread use of submission and signature technology, ...