Browsing Theses and Dissertations, Electronic (ETDs) by Title
Now showing items 1084-1103 of 2498
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Identification and Applications of Llama-Derived Single Domain Antibodies Binding to Glycoprotein D of Herpes Simplex Virus 2
(Johns Hopkins University, 2013-12-06)There are currently no protective vaccines or microbicides that can prevent the transmission of herpes simplex virus 2 (HSV-2). The purpose of this thesis was to develop a microbicide based on a llama-derived single domain ... -
Identification and Characterization of a Stem Cell-Like Population in Ovarian Cancer
(Johns Hopkins University, 2014-01-31)Eighty percent of patients with advanced ovarian cancer show an initial clinical response to therapy, but seventy-five percent of these patients eventually relapse. This transient clinical response would be consistent ... -
Identification and Characterization of Histone H3 Lysine 23 Methylation in Germline Chromatin
(Johns Hopkins UniversityUSA, 2014-02-28)Eukaryotic DNA and histone proteins are packaged into chromatin that can occur in two cytologically distinct states: heterochromatin, which is highly compacted and transcriptionally repressive; or euchromatin, which is ... -
Identification and characterization of novel factors needed for two aspects of Myxococcus xanthus physiology: social motility and osmoregulation
(Johns Hopkins University, 2013-11-07)Myxococcus xanthus is a non-pathogenic Gram-negative, delta proteobacterium. This bacterium has become an important model system for the study of complex bacterial phenomena such as cell-to-cell communication, motility, ... -
IDENTIFICATION AND ELUCIDATION OF MIR-214 AND MIR-29A AS POTENT REGULATORS OF LIVER FIBROSIS
(Johns Hopkins University, 2013-12-13)Liver fibrosis is the accumulation of extracellular matrix proteins in response to hepatocellular injury. Worldwide, liver fibrosis and cirrhosis accounts for nearly 160,000 deaths per year. It results from many different ... -
Identification of a role for B7-H4 in neutrophil homeostasis and innate immunity
(Johns Hopkins University, 2014-03-27)B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T cell responses. To explore physiological roles of B7-H4, we created B7-H4-deficient (KO) mice by genetic targeting. B7-H4KO mice are healthy ... -
Identification of an inhibitory domain in RAG-2 that gates access of the V(D)J recombinase to chromatin
(Johns Hopkins UniversityUSA, 2017-03-22)V(D)J recombination is initiated by a specialized transposase consisting of the subunits RAG-1 and RAG-2. The susceptibility of gene segments to DNA cleavage by the V(D)J recombinase is correlated with epigenetic modifications ... -
IDENTIFICATION OF INCOMPLETE INFORMATION GAMES WITH MULTIPLE EQUILIBRIA AND UNOBSERVED HETEROGENEITY
(Johns Hopkins UniversityUSA, 2014-06-11)This dissertation mainly studies identification of finite action games with incomplete information. The essential contribution of this dissertation is to allow for the presence of multiple equilibria and/or unobserved ... -
Identification of Non-Traditional Molecular Contributors to Cystic Fibrosis
(Johns Hopkins UniversityUSA, 2016-06-14)Next generation sequencing has enabled the identification of patients with unambiguous recessive Mendelian phenotypes and incomplete genotypes, meaning zero or only one disease-causing mutation are detected by diagnostic ... -
IDENTIFICATION OF NOVEL GANGLIOSIDE-ASSOCIATED PROTEINS AND ADVANCES IN SINGLE-CELL GANGLIOSIDE METABOLOMICS IN NERVE CELLS
(Johns Hopkins UniversityUSA, 2013-09-23)Gangliosides, glycosphingolipids that carry at least one sialic acid residue, are enriched in the plasma membranes of neurons. Despite their abundance, little is known about the molecules they interact with in the plasma ... -
IDENTIFICATION OF PANCREATIC CANCER-SPECIFIC ANTIGENS USING A NOVEL QUANTITATIVE SEROPROTEOMICS APPROACH
(Johns Hopkins UniversityUSA, 2014-03-19)Pancreatic ductal adenocarcinoma (PDA) is among the most deadly cancers with less than 5% of the patients living beyond 5 years after diagnosis. Lack of early diagnostic biomarkers and resistance to current therapies help ... -
IDENTIFICATION OF SOURCES OF POLLUTANTS IN BALTIMORE HARBOR
(Johns Hopkins University, 2014-05-09)Nutrient and sediment pollution are important issues in Baltimore Harbor. The poor water quality has affected human activities and lives in the Harbor. This report applied Chesapeake Bay Phase 5.3 Watershed Model output ... -
Identification of the Roles of the Small Ubiquitin-Related Modifier (SUMO) in Cellular Stress Response
(Johns Hopkins University, 2015-04-10)Proper protein folding is essential for cell function, as misfolding leads to cell stress and cytotoxicity. Misfolded proteins are associated with several serious diseases in humans such as Parkinson’s and Alzheimer’s ... -
IDENTIFICATION OF U6 PROMOTERS FOR CRISPR-CAS9 GENOME ENGINEERING IN AEDES AEGYPTI
(Johns Hopkins UniversityUSA, 2018-04-25)Aedes aegypti is the primary vector of Zika and Dengue viruses. The objective of this study was to identify a functional U6 snRNA promoter for plasmid-based sgRNA expression and CRISPR-Cas9 genome engineering in Ae. aegypti. ... -
IDENTIFYING AND CORRECTING COGNITIVE BIASES IN SUBJECTIVE PROBABILITY ELICITATION SURVEYS: MODEL BASED APPROACHES
(Johns Hopkins UniversityUSA, 2016-02-22)As probability elicitation becomes widely used, methods other than one-on-one interviews are being used to elicit expert probabilities. This thesis considers biases that may arise when probabilities are elicited in an ... -
IDENTIFYING AND OVERCOMING BARRIERS IN THE TRANSLATION OF ETIOLOGIC CANCER BIOMARKERS
(Johns Hopkins UniversityUSA, 2017-07-11)Background: With the goal to improve the translation of cancer biomarkers, this dissertation examined strategies to overcome two barriers in the practice of translational epidemiology: Aim 1) practice of multidisciplinary ... -
Identifying novel genes involved in amino acid sensing
(Johns Hopkins UniversityUSA, 2014-02-03)TOR (target of rapamycin) is a conserved serine/threonine kinase that forms two key complexes, TORC1 and TORC2 that regulate many different pathways in the cell including cell growth and autophagy. The TOR pathway promotes ... -
IDENTIFYING PROTEIN-PROTEIN INTERACTION INHIBITORS TARGETING APICOMPLEXAN ATG8-ATG3 INTERACTIONS
(Johns Hopkins UniversityUSA, 2016-08-04)Malaria is a global health crisis that threatens almost half of the world’s population. The need for novel antimalarials is becoming increasingly urgent as the incidence of resistance rises against the first-line defense, ... -
Identifying the Substrate Specificities of SENP1 and SENP2 in Recognition of Sumoylated Thymine-DNA Glycosylase
(Johns Hopkins UniversityUSA, 2018-04-26)SUMO is an essential post-translational protein modification regulated in part by the activity of a family of SUMO-specific proteases known as SENPs. Mammalian cells express six different SENPs with essential and non-redundant ... -
“If I did not slap you, you would not have given birth to your baby”: The mistreatment of women during childbirth
(Johns Hopkins UniversityUSA, 2016-02-26)Background Evidence suggests that women experience mistreatment during childbirth in facilities across the world, including physical and verbal abuse, discrimination and neglect. However, there is no agreed-upon definition ...