Browsing Theses and Dissertations, Electronic (ETDs) by Title
Now showing items 3654-3673 of 6070
-
N-GLYCOPEPTIDEATLAS: A DATABASE FOR SPECTRA LIBRARY OF N-LINKED GLYCOSYLAYION
(Johns Hopkins UniversityUSA, 2020-05-11)In the field of glycoproteomic glycosylation and glycopeptides are essential for people to study. It is even more imperative to build a database that contains all the N-linked glycopeptides and its corresponding mass ... -
NAD LIMITATION AND ITS IMPACT ON C. GLABRATA SURVIVAL AND VIRULENCE
(Johns Hopkins UniversityUSA, 2016-10-05)This work describes what happens in cells that are starved for NAD+. Candida glabrata is an opportunistic yeast pathogen that is an NAD+ auxotroph and limitation of NAD+ in media leads to transcriptional activation of key ... -
Naming the Master: The Evolving Significances of "Victor Hugo" in 19th-Century French Literature
(Johns Hopkins UniversityUSA, 2016-03-17)No name dominates the literature of the French 19th Century—and after—as pervasively as Victor Hugo’s. Thanks to this ubiquity, the evolving meanings of this name are visible in works by Hugo and by those who wrote under ... -
NANO-SCALE CHARGE SEPARATION IN PdTeI AND PEROVSKITE PHOTOVOLTAIC DEVICES OBSERVED BY CRYSTALLOGRAPHY AND TEMPERATURE-DEPENDENT PHOTOCURRENT SPECTROSCOPY
(Johns Hopkins UniversityUSA, 2015-06-08)Charge separation in the solid state is a process that is fundamental to technologies such as heterogenous catalysts, batteries, and photovoltaics. Additionally, spontaneous charge separation occurs as part of certain ... -
Nano-structured, drug-eluting medical devices for improved clinical outcomes
(Johns Hopkins UniversityUSA, 2017-03-24)The biological response to implanted medical devices is critical to the success of surgical procedures. Implantation of foreign devices into the body increases infection risk and may cause inflammation, both of which can ... -
Nanofiber-based tissue engineering scaffolds for repairing injured nerves and soft tissues
(Johns Hopkins UniversityUSA, 2015-08-28)One objective of the field of tissue engineering is to develop new biomaterials to unlock the body’s own potential to rebuild itself. Electrospun nanofibers are one such material, providing topographical features on the ... -
Nanoparticle Adsorption at Fluid Interfaces
(Johns Hopkins UniversityUSA, 2018-02-27)Nanoparticles (NPs) adsorption can add functionality (e.g., catalytic, optical, rheological) to fluid interfaces. NPs can also stabilize fluid interfaces to allow for complex droplet shapes, bijels, and buckled microstructures. ... -
Nanoparticle Based siRNA Delivery to the Central Nervous System: A Potential Therapeutic Approach
(Johns Hopkins UniversityUSA, 2015-03-26)Efficient delivery of siRNA via nanoparticles may emerge as a viable therapeutic approach to treat central nervous system disorders including Alzheimer’s Disease (AD), a progressive neurodegenerative disease currently ... -
Nanoparticle delivery of DNA, siRNA, and miRNA for the treatment of glioblastoma
(Johns Hopkins UniversityUSA, 2016-11-18)The overall goal of the thesis is to explore novel nanotechnologies for the treatment of brain cancer. In particular, we used nanoparticles to deliver nucleic acid cargoes to glioblastoma (GBM) with the goal of altering ... -
Nanoparticle polymer composite applications and environmental impacts
(Johns Hopkins UniversityUSA, 2018-07-20)The polymer composite field has significantly benefited from the inclusion of nanoparticles (NP) that impart size-dependent properties. In water filtration, containment removal and fouling rate are improved when available ... -
NANOPARTICLE-MEDIATED TRANSCRIPTIONAL REGULATION OF STEM AND PROGENITOR CELLS FOR PERIPHERAL NERVE REGENERATION
(Johns Hopkins UniversityUSA, 2016-10-25)Schwann cells offer great promise in treating peripheral nerve injuries as they can assist in clearing debris, provide trophic support, and importantly, remyelinate regenerating axons, but there are no readily available ... -
Nanophotonic design and nanomaterial assembly for next-generation optoelectronics
(Johns Hopkins UniversityUSA, 2019-07-15)Nanomaterials are widely deployed in many optoelectronic technologies, with applications in solar energy harvesting, light emission, bio-sensing, computing and communications. The unique advantages of colloidal nanomaterials ... -
Nanopore DNA Sequencing to Expand Genetic Context in Non-Model Species Research
(Johns Hopkins UniversityUSA, 2021-05-10)Advances in DNA sequencing technologies have dramatically transformed the scale and speed at which molecular evolution can be observed. As genome sequencing costs decrease and capacity becomes increasingly ubiquitous, new ... -
Nanopore Sequencing for Investigation of the Human Epigenome
(Johns Hopkins UniversityUSA, 2020-06-05)The invention of next generation sequencing (NGS) revolutionized the field of human genetics, providing a practical way to study genetics in a genome-wide fashion. With the ability to sequence the whole genome came the ... -
NANOSCALE PATTERNING AND 3D ASSEMBLY FOR BIOMEDICAL APPLICATIONS
(Johns Hopkins UniversityUSA, 2014-07-15)Due to the inherent planarity of nanoscale patterning, there is a pressing need to develop novel approaches for parallel and cost-effective three dimensional (3D) patterning and assembly at the nanoscale. The 3D devices ... -
Nanotechnology for the understanding and prevention of preterm birth
(Johns Hopkins UniversityUSA, 2020-07-02)Preterm birth (PTB) affects nearly 15 million infants each year. Of these PTBs, more than 25% are a result of inflammation or infection. One way in which the uterus can become inflamed is via bacterial ascension from the ... -
NARKAR DISSERTATION - On the role of P53 in the cellular response to aneuploidy
(Johns Hopkins UniversityUSA, 2020-07-09)A majority of solid tumors are aneuploid and the tumor suppressor protein 53, has been implicated as the guardian of euploid genomes in animal organisms. Experiments using transformed or non-transform human cell lines ... -
NATION BUILDING AFTER 9/11: NATION BUILDING AS AN ANTI-TERRORISM TOOL UNDER THE MILITARY’S LEADERSHIP AND BUILDING THE AFGHAN STATE
(Johns Hopkins University, 2014-06-02)In the post 9/11 environment nation building is often viewed as an anti-terrorism tool. This thesis examines post 9/11 nation building with a focus on 1) whether nation building secures a lasting victory against anti-American ... -
NATIONAL FAMILY CAREGIVER SUPPORT PROGRAM (NFCSP): ASSESSING CLIENTS’ CHARACTERISTICS, PROGRAM UTILIZATION AND DIFFICULTY ACCESSING SERVICES
(Johns Hopkins UniversityUSA, 2018-04-23)Objective: This dissertation examined the National Family Caregiver Support Program (NFCSP), assessing NFCSP clients based on their demographic and health characteristics, caregiving-related burden and circumstances, and ... -
NATIONAL SECURITY CONSIDERATIONS AND DOMESTIC LAND PROTECTION EFFORTS: DO U.S. SENATORS FIND COMMON GROUND?
(Johns Hopkins UniversityUSA, 2020-08-25)What national security concerns, if any, do U.S. Senators consider relevant to domestic land protection issues? Past research on the nexus between national security and land protection reveals growing awareness of the ...