Now showing items 1-2 of 2
Elucidating differences in the conformational dynamics of K-Ras isoforms
(Johns Hopkins University, 2015-05-15)
Humans ubiquitously express three genes (HRAS, KRAS, and NRAS) that encode four different isoforms of Ras, an integral p21 GTPase acting as an effector of cell surface receptors and regulating cell survival, proliferation, ...
EXAMINING PROTEIN CONFORMATIONAL DYNAMICS USING COMPUTATIONAL TECHNIQUES: STUDIES ON PHOSPHATIDYLINOSITOL-3-KINASE AND THE SODIUM-IODIDE SYMPORTER
(Johns Hopkins University, 2022-09-01)
Experimental biophysics techniques used to study proteins, polymers of amino acids that comprise most therapeutic targets of human disease, face limitations in their ability to interrogate the continual structural fluctuations ...