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ANALYZING THE ROLE OF COVALENT MODIFICATIONS TO AN ARYL CARRIER PROTEIN IN DIRECTING SEQUENTIAL INTERACTIONS IN YERSINIABACTIN SYNTHETASE
(Johns Hopkins University, 2016-06-08)
Nonribosomal peptide synthetases (NRPSs) are enzymatic systems found in bacteria and fungi responsible for the production of complex secondary metabolites. NRPSs are able to generate a remarkably diverse array of natural ...
SPATIOTEMPORAL DYNAMICS AND REGULATION OF CYCLIC NUCLEOTIDES AND THEIR EFFECTORS IN LIVING CELLS
(Johns Hopkins University, 2016-09-13)
Cellular signaling is a tightly regulated process which defines how cells interact with their environment and maintain homeostasis. It is also the mechanism by which they change. Neuronal development is one such process ...
Cyclic Nucleotide Regulation of Excitation-Contraction Coupling in Cardiac Myocytes
(Johns Hopkins University, 2016-05-02)
The balanced signaling between the two cyclic nucleotides (cNs) cAMP and cGMP in the cN cross-talk signaling network plays a critical role in regulating cardiac contractility. In particular, the signaling network imposes ...
T Cell Effector Responses in HIV-1 Cure Strategies
(Johns Hopkins University, 2016-05-12)
HIV-1 is a virus that affects over 35 million individuals around the world, and yet despite present treatments, there remains a need for a cure. A current cure tactic widely researched is the “shock and kill” strategy, ...
ULTRA-SENSITIVITY OF CELL ADHESION IN A MECHANICALLY HETEROGENOUS ENVIRONMENT
(Johns Hopkins University, 2016-08-18)
Cell adhesion regulates critical cellular functions in adherent cells. Yet, the fundamental mechanism during the early events in cell adhesion remains unclear. At the most elementary level, cell processes its environment ...
Network modeling and optimization for energy and sustainable transit
(Johns Hopkins University, 2016-05-06)
Energy and transportation systems are integral to our infrastructure. Along with
other types of networks, critical challenges constantly arise, particularly with regard to accessibility, efficiency, optimality, and ...
Resilience of Healthcare in Disasters: a Systems Approach
(Johns Hopkins University, 2016-05-06)
Healthcare systems have been identified worldwide as critical infrastructure which must continue to function in order for communities to survive natural disasters such as earthquakes, floods, and hurricanes. In a time in ...
RELATE TO MOTIVATE: AN INVESTIGATION OF AN ONLINE INTERVENTION GEARED TOWARD INCREASING MOTIVATION AND COLLEGE AND CAREER READINESS IN STUDENTS FROM BACKGROUNDS OF POVERTY
(Johns Hopkins University, 2016-07-21)
Students from low socioeconomic statuses are faced with a double bind. Not only are they often in settings with limited resources, but they face an academic achievement gap from their wealthier peers which often keeps ...
FUNCTIONS OF THE SEVENTEEN KILODALTON PROTEIN IN ESCHERICHIA COLI PROTEOSTASIS
(Johns Hopkins University, 2016-07-15)
Outer membrane (OM) biogenesis is critical for the survival of Gram-negative bacteria. This process depends on periplasmic protein homeostasis, or proteostasis. Proteostasis depends on quality control (QC) networks. However, ...
Communication, Empire, and Authority in the Qing Gazette
(Johns Hopkins University, 2016-06-21)
This dissertation studies the political and cultural roles of official information and political news in late imperial China. Using a wide-ranging selection of archival, library, and digitized sources from libraries and ...