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Nucleotide Resolution Analysis of Recurrent Rearrangements in Prostate Cancer and Their Utility in Defining Clonal Disease Progression
(Johns Hopkins University, 2015-10-07)
Genomic structural variation is a hallmark of prostate cancer (PCa) and recurrent rearrangements involving androgen regulated genes and ETS family transcription factors occur in 30-70% of cases. These rearrangements represent ...
Computational Approaches to Reconstruction of Cancer Evolutionary Histories from Multi-region Next Generation Sequencing Data
(Johns Hopkins University, 2017-05-30)
Clonal evolution model of cancer provides a conceptual framework to interpret spatial and temporal intra-tumor heterogeneity, and has survived several decades of experimental validation. The increasing accuracy and decreasing ...
Developing Single-Molecule Augmented Capture (SMAC) to Detect Biomarkers in Human Blood
(Johns Hopkins University, 2018-12-11)
The ability to accurately identify and characterize individual biomarker proteins in patient blood samples could improve diagnosis of diseases at an earlier stage, when treatment is typically more effective. Current blood ...
Engineering Biomaterial Properties for T Cell Immunotherapy
(Johns Hopkins University, 2019-02-28)
Immune cell therapies have revolutionized our idea of a drug. Essentially they are a living drug becoming increasingly used because of their specificity (antigen targeting), durability (memory cells), and success seen in ...
COM701, A FIRST-IN-CLASS IMMUNE CHECKPOINT INHIBITOR, TARGETS A NOVEL TUMOR PROMOTING PATHWAY MEDIATED BY PVRIG LIGATION TO PVRL2
(Johns Hopkins University, 2018-07-31)
Cancer is a leading public health crisis facing adults in the United States, with estimations that greater than 1.7 million new cancer cases and over 600,000 cancer-related deaths will occur in 2018. While the cost of ...
VISCOSITY INDUCED CELLULAR ADAPTATIONS FOR INCREASED CELL MOTILITY
(Johns Hopkins University, 2020-05-12)
Cancer, a disease with significant dependence on genetic predisposition, is caused when an epithelial cell undergoes mutation and multiplies clonally in a direction away from the vascular supply to form a tumor. Cancer-related ...
The Impact of Highly Active Antiretroviral Therapy on Cancer Survival in the Multicenter AIDS Cohort Study and the Women’s Interagency HIV Study
(Johns Hopkins University, 2015-04-24)
OBJECTIVES: To characterize and compare cancer survival among HIV-infected and –uninfected individuals diagnosed with cancer in the pre-HAART (1984-1994) and the HAART (1995-2013) eras, and to describe cancer survival in ...
Circulating tumor DNA in the cancer care continuum
(Johns Hopkins University, 2019-08-28)
Circulating tumor DNA (ctDNA) analysis has become a valuable tool for the investigation of cancer biomarkers in both early- and late-stage scenarios. To evaluate the utility of ctDNA as a biomarker of response in patients ...
EXPLORING CANCER PREVENTION AND SCREENING INFORMATION ENGAGEMENT ON FACEBOOK AMONG U.S. LATINOS
(Johns Hopkins University, 2020-04-09)
Latinos, the largest minority in the U.S., face a high burden of cancer, making it important to deliver evidence-based cancer prevention and screening information (CPSI) to them. Social media presents an innovative platform ...
DECIPHERING THE ROLE OF DNMT3B IN REGULATING DNA METHYLATION AND EPIGENETIC MODULATION OF TRANSCRIPTIONAL SILENCING
(Johns Hopkins University, 2014-07-02)
DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. DNA methylation patterns are not randomly distributed, instead they are compartmentalized by region. In normal cells ...