Now showing items 1-10 of 12
Advancing Magnetic Resonance Spectroscopy and Endoscopy with Prior Knowledge
(Johns Hopkins University, 2014-06-09)
Reconstruction is key to the generation of anatomic, functional and biochemical information in the field of Magnetic Resonance (MR) in medicine. Here, prior knowledge based on various conditions is utilized through ...
GREMLIN: Graph Estimation From MR Images Leading to Inference in Neuroscience
(Johns Hopkins University, 2016-05-02)
In recent years there has been a growing desire to understand the structure and function of the human brain. Approximately 1 in 5 adults suffers from mental illness, and many of these illnesses, including Alzheimer's ...
Statistical methods for epigenetic data and structural magnetic resonance imaging
(Johns Hopkins University, 2016-04-04)
This dissertation introduces novel statistical methods for the analysis of high-dimensional biomedical data. First, we present a normalization method for DNA methylation microarray data, called Functional normalization ...
NOVEL MRI APPROACHES FOR QUANTITATIVE ASSESSMENT OF CORONARY ARTERIES AND VENTRICULAR FUNCTION
Despite advances in screening techniques and prevention guidelines, cardiovascular disease remains the leading non-communicable disease with 17 million deaths worldwide in 2008. Approximately 6% of American adults had a ...
Steady-state Susceptibility Contrast MRI of Breast Cancer Angiogenesis: Preclinical Validation and Application
Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...
DEVELOPMENT AND APPLICATION OF NOVEL PHYSIOLOGICAL MRI METHODS TO IMAGE CHANGES IN OXYGENATION
This dissertation details the application of novel MRI methods (VASO and APT MRI) to acute stroke as well as the work to develop a novel MRI technique to image oxygenation in the brain.
Co-registration of Bioluminescence Tomography and Anatomical Imaging Modalities for Cell Tracking and Source Quantification
Bioluminescence tomography (BLT) is a molecular imaging tool that provides three-dimensional, quantitative reconstructions of bioluminescent sources in vivo. A main limitation of BLT to date, however, has been a lack of ...
IN VIVO DIFFUSION WEIGHTED MAGNETIC RESONANCE SPECTROSCOPY IN MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is a complex CNS disease in which inflammation, demyelination and neuroaxonal degeneration are concurrent processes. MS therapies developed to date are directed at the immune-mediated, inflammatory ...
STATISTICAL METHODS FOR AUTOMATIC BRAIN SEGMENTATION
Background: Automatic segmentation of the brain into cerebrospinal fluid (CSF), grey matter (GM), and white matter (WM) has been of interest for over twenty years. As magnetic resonance imaging (MRI) has improved and new ...
The 3D Knee: Visualizing Real Data from 3D Magnetic Resonance Neurography
Established 2D MRI techniques are of limited clinical usefulness for visualizing of small peripheral cutaneous nerves of the knee due to limitations in spatial resolution and partial volume averaging effects. This leads ...