Now showing items 1-10 of 16
HYPOXIA-INDUCIBLE FACTORS ENHANCE GLUTAMATE SIGNALING IN CANCER CELLS
(Johns Hopkins University, 2014-06-18)
Hypoxia-inducible factors (HIFs) are transcription factors that are essential in many developmental, physiological and pathophysiological processes. HIFs can be induced in response to reduced oxygen availability (hypoxia) ...
Elucidating differences in the conformational dynamics of K-Ras isoforms
(Johns Hopkins University, 2015-05-15)
Humans ubiquitously express three genes (HRAS, KRAS, and NRAS) that encode four different isoforms of Ras, an integral p21 GTPase acting as an effector of cell surface receptors and regulating cell survival, proliferation, ...
Risk factors for oral HPV persistence and HPV-associated cancer
(Johns Hopkins University, 2016-03-14)
Background: Persistent human papillomavirus (HPV) infection is a well-known cause of cervical and anogenital cancers. In the past decade, oral HPV infection was established as a cause of oropharyngeal squamous cell carcinoma ...
Engineering Of Polymer/DNA Nanoparticles To Improve Gene Delivery Efficiency In Vivo
(Johns Hopkins University, 2015-08-21)
Nanoparticle-mediated non-viral gene delivery offers an exciting alternative to conventional viral vectors. However, a main roadblock to their future clinical application lies in the poor therapeutic delivery efficiency ...
How does keratin 17 control gene expression?
The type I intermediate filament protein keratin 17 has been long implicated as a meaningful biomarker for a broad range of carcinomas (Moll et al., 1982), and there is emerging evidence that its expression impacts ...
CREDENTIALING THE DNA METHYLATION MAINTENANCE PROTEIN UHRF1 AS A TARGET FOR ANTICANCER THERAPY
Cancer is a disease of genome alterations that drive uncontrolled growth. The most challenging aspect of cancer treatment is that there are many avenues to enable proliferation within the cell, including alterations to ...
CYTOSOLIC PROTEIN INTERACTION WITH THE VOLTAGE DEPENDENT ANION CHANNEL OF THE MITOCHONDRIAL OUTER MEMBRANE CONTROLS CELLULAR RESPIRATION
The voltage dependent anion channel (VDAC) is a beta-barrel protein that spans the mitochondrial outer membrane and serves as the passageway for the flux of metabolites responsible for mitochondrial function. It was ...
An Exploration of the Role of Family Members in Pre-Surgical Visits
(Johns Hopkins University, 2017-07-11)
There were 46 visits (75%) in which companions were present, and 15 (25%) in which companions were not present.
Radio-morphology: Parametric Shape-Based Features in Radiotherapy
(Johns Hopkins University, 2017-12-18)
In radiotherapy, it is necessary to characterize dose over the patient anatomy to target areas and organs at risk. Current tools provide methods to describe dose in terms of percentage of volume and magnitude of dose, but ...
Development of cancer biomarker assays from dna in various bodily fluids
(Johns Hopkins University, 2017-05-18)
Abstract DNA from cancer cells can enter surrounding fluid after apoptosis or necrosis. This DNA can be identified by sampling and sequencing the fluid looking for the mutations that gave rise to the cancer, referred to ...