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OXYGEN GRADIENTS AND EXTRACELULLAR MATRIX INTERACTIONS SYNERGISTIC EFFECT ON SARCOMA CELL MIGRATION
(Johns Hopkins University, 2018-04-06)
Soft tissue sarcomas are a heterogeneous group of malignant cancers derived from transformed cells of mesenchymal origin. Approximately 13,000 new cases per year are diagnosed in the US alone, with 25–50% of patients ...
ENDOTHELIAL PROGENITOR CELL RECRUITMENT IN A WOUND HEALING MICROFLUIDIC VASCULAR MODEL
(Johns Hopkins University, 2014-12-02)
During wound healing, endothelial progenitor cells (EPCs) are recruited from the bone marrow and directed to the site of injury. At the site of injury, hypoxic conditions promote TNF-α, which up regulates intercellular ...