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UNCOVERING THE EPIDEMIOLOGY OF COVID-19: JUST-IN-TIME SCIENCE IN A PANDEMIC
(Johns Hopkins University, 2020-10-30)
COVID-19 pandemic has led to over 30 million reported cases 10 month after it was first detected. This dissertation presents results generated as the pandemic emerged to better understand the epidemiology of the disease, ...
Inhibition of Essential Protein-Protein Interactions in Plasmodium and SARS-CoV-2
(Johns Hopkins University, 2021-05-05)
Plasmodium
Malaria is caused by Plasmodium parasites. A critical step during merozoite entry into red blood cells (RBCs) is the formation of a tight junction between the parasite and RBC, as it commits the parasite for ...
RISK OF COVID-19 MOVEMENT AND EXPOSURE ON PASSENGER RAILCARS: ASSESSMENT OF AEROSOL TRANSPORT AND RAILCAR VENTILATION SYSTEMS
(Johns Hopkins University, 2021-06-09)
We conducted a series of static and dynamic experiments in a fleet of passenger railcars and locomotives for a large-scale, mass-transit company to measure the: (1) aerosol concentrations corresponding to respirable-sized/viral ...
FROM microRNAS TO MITOCHONDRIA IN THE MACROPHAGE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS: AND INFLAMMASOME ACTIVATION IN COVID-19
(Johns Hopkins University, 2021-03-24)
Tuberculosis (TB) and COVID-19 are two major infectious disease problems. While TB is caused by a slow growing bacterium, Mycobacterium tuberculosis (Mtb), and COVID-19 is caused by a virus, severe acute respiratory syndrome ...
PREVENTION, TESTING, AND SYNDROMIC SURVEILLANCE OF COVID-19: A PROSPECTIVE COHORT STUDY OF ELECTRONIC CIGARETTE USERS IN THE UNITED STATES
(Johns Hopkins University, 2021-05-04)
Background
Electronic cigarette (EC) use is prevalent and harmful among young adults. Recent surveys suggested increased testing and risks of coronavirus disease 2019 (COVID-19) associated with EC use. Longitudinal studies ...
FAMILY WELL-BEING AND THE COVID-19 PANDEMIC IN THE UNITED STATES
(Johns Hopkins University, 2021-04-05)
Background
The COVID-19 pandemic has caused widespread infection, school closures, and high rates of job loss. Much of the current research has focused on the clinical features of COVID-19 infection, but the family well-being ...
The COVID-19 pandemic and its effects on medication usage
(Johns Hopkins University, 2021-05-12)
Nearly everyone in the world has been affected by the COVID-19 pandemic. Hundreds of thousands of people have died in the US alone, jobs have been lost, family and friends have been separated both physically and emotionally, ...
DEVELOPMENT OF NOVEL TOOLS TO THERAPEUTICALLY MODULATE AND MODEL THE IMMUNE RESPONSE TO CANCER AND INFECTION
(Johns Hopkins University, 2021-08-03)
Even with the prolific clinical use of next-generation cancer immuno-therapeutics, many tumors remain unresponsive or become refractory to therapy, demonstrating the ongoing medical need for additional strategies. This ...
Early Prediction of Adverse Clinical Events and Optimal Intervention in Intensive Care Units
(Johns Hopkins University, 2021-10-26)
Adverse clinical events like cardiopulmonary arrest and multiple organ dysfunction are life-threatening events with potentially debilitating health outcomes and are a leading cause for mortality in intensive care unit (ICU) ...
COVID-19 Impact on Genetic Counseling for Huntington's Disease via Telehealth
(Johns Hopkins University, 2021-12-10)
Huntington’s disease (HD) is a severe, heritable, adult-onset neurological disorder that impairs mood, movement, cognition, and behavior, with a life expectancy of 15-20 years following onset of symptoms. HD is caused by ...