Now showing items 1-4 of 4
Epigenetic Control of Functional Axon Regeneration
(Johns Hopkins University, 2017-09-01)
The failure of central nervous system axons to regenerate is a known consequence of traumatic injury and neurodegenerative disease. The central nervous system’s regenerative capacity starkly contrasts with the peripheral ...
Improving productivity of CHO cell lines through genome editing, a better understanding of the epigenome and addition of hydrolysates
(Johns Hopkins University, 2017-07-21)
Mammalian cells act as an ideal host for the production of recombinant proteins and therapeutics, with CHO cells being the most preferred. With increasing demands for protein therapeutics, it has become important to optimise ...
A case-control epigenome-wide study of schizophrenia
(Johns Hopkins University, 2017-03-15)
Schizophrenia (SZ) is severe neuropsychiatric disorder with significant costs to the individual and society. Accumulating evidence points to the role of DNA methylation (DNAm) in either pathogenesis or as a biomarker of ...
WHOLE-GENOME BISULFITE SEQUENCING REVEALS GENOMIC REGIONS VULNERABLE TO EPIGENETIC PERTURBATION
(Johns Hopkins University, 2017-08-30)
Environmental exposures that alter epigenetic marks can have phenotypic consequences for multiple generations. Prenatal nutrition and environmental stressors have been shown to frequently alter DNA methylation at ...