Now showing items 1-7 of 7
STATISTICAL METHODS FOR AUTOMATIC BRAIN SEGMENTATION
(Johns Hopkins University, 2014-12-18)
Background: Automatic segmentation of the brain into cerebrospinal fluid (CSF), grey matter (GM), and white matter (WM) has been of interest for over twenty years. As magnetic resonance imaging (MRI) has improved and new ...
Steady-state Susceptibility Contrast MRI of Breast Cancer Angiogenesis: Preclinical Validation and Application
(Johns Hopkins University, 2014-02-07)
Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...
Co-registration of Bioluminescence Tomography and Anatomical Imaging Modalities for Cell Tracking and Source Quantification
(Johns Hopkins University, 2014-05-05)
Bioluminescence tomography (BLT) is a molecular imaging tool that provides three-dimensional, quantitative reconstructions of bioluminescent sources in vivo. A main limitation of BLT to date, however, has been a lack of ...
DEVELOPMENT AND APPLICATION OF NOVEL PHYSIOLOGICAL MRI METHODS TO IMAGE CHANGES IN OXYGENATION
(Johns Hopkins University, 2014-01-24)
This dissertation details the application of novel MRI methods (VASO and APT MRI) to acute stroke as well as the work to develop a novel MRI technique to image oxygenation in the brain.
IN VIVO DIFFUSION WEIGHTED MAGNETIC RESONANCE SPECTROSCOPY IN MULTIPLE SCLEROSIS
(Johns Hopkins University, 2015-03-26)
Multiple sclerosis (MS) is a complex CNS disease in which inflammation, demyelination and neuroaxonal degeneration are concurrent processes. MS therapies developed to date are directed at the immune-mediated, inflammatory ...
The 3D Knee: Visualizing Real Data from 3D Magnetic Resonance Neurography
(Johns Hopkins University, 2015-03-24)
Established 2D MRI techniques are of limited clinical usefulness for visualizing of small peripheral cutaneous nerves of the knee due to limitations in spatial resolution and partial volume averaging effects. This leads ...
NOVEL MRI APPROACHES FOR QUANTITATIVE ASSESSMENT OF CORONARY ARTERIES AND VENTRICULAR FUNCTION
(Johns Hopkins University, 2014-06-02)
Despite advances in screening techniques and prevention guidelines, cardiovascular disease remains the leading non-communicable disease with 17 million deaths worldwide in 2008. Approximately 6% of American adults had a ...