Now showing items 1-5 of 5
Detection of PIK3CA Mutations in Plasma Tumor DNA Circulating in Peripheral Blood of Breast Cancer Patients
(Johns Hopkins University, 2014-04-10)
Tumor-specific mutations are used as genetic biomarkers for breast cancer diagnosis and prognosis. The detection and quantification of mutations in tumor DNA circulating in peripheral blood offers a non-invasive approach ...
Synthesizing Data Sources to Develop and Update Risk Models
(Johns Hopkins University, 2014-06-19)
Building risk models from multiple different sources of data allows researchers to incorporate the best available information on key model parameters. In this thesis, we develop and apply methodology for optimally combining ...
THE HOMEOBOX PROTEIN HOXC10 IS OVEREXPRESSED IN BREAST CANCER AND INCREASES RESISTANCE TO CHEMOTHERAPY
(Johns Hopkins University, 2013-10-16)
Background. Drug resistance is a major limiting factor in the success of targeted cancer therapies resulting in failure of treatment. A molecular understanding of the underlying mechanisms is essential to predict, prevent ...
COMBINATION IMMUNOTHERAPY TARGETING IMMUNOSUPPRESSIVE SIGNALS IN THE TUMOR MICROENVIRONMENT PREVENTS CANCER PROGRESSION IN BREAST AND PANCREATIC CANCER
(Johns Hopkins University, 2015-02-17)
Mechanisms of immune tolerance and suppression occur early at the site of developing tumors and inhibit protective responses induced by cancer vaccines, limiting their efficacy in the treatment of cancer. Combinatorial ...
Steady-state Susceptibility Contrast MRI of Breast Cancer Angiogenesis: Preclinical Validation and Application
(Johns Hopkins University, 2014-02-07)
Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...