Now showing items 1-5 of 5
CREDENTIALING THE DNA METHYLATION MAINTENANCE PROTEIN UHRF1 AS A TARGET FOR ANTICANCER THERAPY
(Johns Hopkins University, 2014-10-01)
Cancer is a disease of genome alterations that drive uncontrolled growth. The most challenging aspect of cancer treatment is that there are many avenues to enable proliferation within the cell, including alterations to ...
Low-grade inflammation, immune capacity, and cancer
(Johns Hopkins University, 2014-10-24)
Inflammation is a well-established etiological factor in carcinogenesis. The immune system may also have the capacity to identify and clear malignant cells in a process known as tumor immunosurveillance. The objective of ...
How does keratin 17 control gene expression?
(Johns Hopkins University, 2014-06-30)
The type I intermediate filament protein keratin 17 has been long implicated as a meaningful biomarker for a broad range of carcinomas (Moll et al., 1982), and there is emerging evidence that its expression impacts ...
CYTOSOLIC PROTEIN INTERACTION WITH THE VOLTAGE DEPENDENT ANION CHANNEL OF THE MITOCHONDRIAL OUTER MEMBRANE CONTROLS CELLULAR RESPIRATION
(Johns Hopkins University, 2014-02-03)
The voltage dependent anion channel (VDAC) is a beta-barrel protein that spans the mitochondrial outer membrane and serves as the passageway for the flux of metabolites responsible for mitochondrial function. It was ...
Testing for hereditary cancer predisposition: the impact of the number of options and a provider recommendation on decision-making outcomes
(Johns Hopkins University, 2015-01-28)
Objective: To examine how the presentation of a decision can influence choices about genetic testing for inherited cancer predispositions. Specifically, how the number of options and the addition of a personalized ...