Now showing items 1-6 of 6
Variations in protein processing lead to variations in structure and function of the HIV-1 envelope protein
(Johns Hopkins University, 2019-01-22)
Mucosal transmission of HIV is a complex, inefficient event that leads to the seeding, and eventual disruption, of the gut-associated lymphoid tissue. The basis for the gut-tropic nature of acute HIV infection is unknown. ...
INVESTIGATING THE POTENTIAL OF RESPONDENT-DRIVEN SAMPLING TO REACH UNDIAGNOSED HIV-INFECTED PEOPLE WHO INJECT DRUGS
(Johns Hopkins University, 2019-03-04)
Background Key populations such as people who inject drugs (PWID) lag behind in the UNAIDS 90-90-90 target, particularly at diagnosis. Respondent-driven sampling (RDS), a referral method that leverages peer network ...
Early Development of Vaginal Microbicides to Decrease HIV Acquisition in Women
(Johns Hopkins University, 2019-06-14)
Women are disproportionately affected by HIV, with most infections in women occurring as a result of heterosexual intercourse. New HIV prevention strategies are needed that women could employ discretely, potentially without ...
The impact of guideline changes on timing of HIV diagnosis, ART uptake, and IPT provision among people living with HIV in South Africa
(Johns Hopkins University, 2019-08-29)
Background South Africa’s National Department of Health adopted universal test and treat (UTT) for people living with HIV (PLHIV) in September 2016. We sought to describe the impact of this policy change on timing of HIV ...
Engineering an iCRISPR HIV Reporter Cell Line to Investigate Mechanisms of Extracellular Vesicle Sensing and HIV Latency
(Johns Hopkins University, 2019-04-18)
The goal of this project is to engineer a human immunodeficiency virus type 1 (HIV-1) reporter cell line with an inducible Cas9 cassette to pave the way for studies of how cells sense the presence of extracellular vesicles ...
Implications of Polysubstance Use and Routes of Drug Administration for Harm Reduction among Rural People Who Inject Drugs
(Johns Hopkins University, 2019-08-22)
Background: The United States is experiencing an opioid crisis. Rural communities, particularly in Appalachia, have been disproportionately affected. Polysubstance use and routes of drug administration, risk factors for ...