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Now showing items 11-20 of 1559
A MICROFLUIDIC DIGITAL MELT PLATFORM FOR SENSITIVE BIOMARKER ANALYSIS AND PARALLELIZED PROFILING OF MOLECULAR HETEROGENEITY
(Johns Hopkins University, 2020-03-20)
Variability in gene regulation is a fundamental characteristic of biology, allowing cellular adaptation in many states, such as development, stress response, and survival. In early disease onset, genetic and epigenetic ...
HOUSEHOLD AIR POLLUTION FROM BIOMASS COOKSTOVES AND A LIQUEFIED PETROLEUM GAS INTERVENTION IN RURAL PERU
(Johns Hopkins University, 2020-03-13)
Problem Statement:
Approximately 3 billion people worldwide, mostly from low and middle-income countries, use biomass fuels such as wood and dung for cooking. Household air pollution (HAP) from biomass cookstoves is ...
Preference encoding in ventral pallidum mediates reward-seeking behavior
(Johns Hopkins University, 2020-03-16)
An essential function of the nervous system is to direct reward-seeking behavior in order to maximize the acquisition of preferred rewards. This process requires a method for evaluating all available outcomes on a common ...
Engineering Skeletal Muscle for Histological and Functional Regeneration Following Volumetric Muscle Loss
(Johns Hopkins University, 2020-03-16)
Tissue engineered skeletal muscle has great potential to successfully treat volumetric muscle loss (VML), a condition with no ideal clinical treatment option. A broad range of engineered muscle constructs have been evaluated ...
Dendrimer-Mediated Targeted Immunotherapies for the Treatment of Glioblastoma
(Johns Hopkins University, 2020-03-17)
Glioblastoma is among the most severe types of cancer, with poor patient prognoses due to barriers associated the brain and solid tumors. Advances in cancer treatments have failed to address glioblastoma because of their ...
Hospital Management, Security, and Performance in Afghanistan
(Johns Hopkins University, 2020-03-16)
Problem Statement: The vulnerability of hospitals in settings of armed conflict is a critical issue of growing public health concern. There remain gaps in the literature regarding the evidence-base for preparedness and ...
THE ROLE OF IN UTERO ENDOTOXIN EXPOSURE IN THE POSTNATAL IMMUNE RESPONSE IN MICE
(Johns Hopkins University, 2020-03-13)
In this body of work, we were interested in both the temporary state of endotoxin tolerance and the gastrointestinal diseases known collectively as inflammatory bowel disease (IBD). Endotoxin tolerance is a state of muted ...
The role of error-based learning in movement and stillness
(Johns Hopkins University, 2020-03-17)
When people and other animals perform a movement that produces an unexpected outcome, they learn from the resulting error and retain a portion of this learning over time. Curiously, for reaching movements of the arm, errors ...
Risks and Benefits of Surgical Preventive Strategies for Ovarian Cancer
(Johns Hopkins University, 2020-04-01)
Ovarian cancer is the deadliest gynecologic cancer and the fifth leading cause of cancer deaths among U.S. women. Due to the lack of effective screening tests, preventive surgeries are a critical component of reducing the ...
THE BRAIN-HEART AXIS: INVESTIGATION OF CARDIAC STRUCTURAL PATHOLOGY AND ASSOCIATION WITH STROKE SUBTYPE AND PATIENT OUTCOMES
(Johns Hopkins University, 2020-04-02)
Ischemic stroke is a deadly disease, with cardioembolic stroke (CS) being particularly costly to patients and their families, due to both high rates of recurrence and the highest rate of mortality, compared to other stroke ...