Now showing items 21-30 of 32
An Exploration of the Role of Family Members in Pre-Surgical Visits
(Johns Hopkins University, 2017-07-11)
There were 46 visits (75%) in which companions were present, and 15 (25%) in which companions were not present.
Novel Methods of Targeting Protein Cytotoxins to Metastatic Prostate Tumors: Teaching "Old Proteins" New Tricks
(Johns Hopkins University, 2017-03-21)
Prostate cancer is among the leading causes of cancer-related death in the United States with 30,000 people succumbing to the disease every year. A vast majority of these men, at the time of diagnosis, presented with distal ...
Inhibition of Glutamine Metabolism Sensitizes Cancer to Further Pharmacological Disruption and Yields Clinically Viable Treatment Options
(Johns Hopkins University, 2018-03-26)
Many cancers are dependent on glutamine and will die or senesce in the absence of glutamine. This phenomenon is knows as, “glutamine addiction.” This work demonstrates that disrupting glutamine metabolism, through glutaminase ...
Rational Cancer Diagnostics Using Rare Mutation Detection Technology With Massively Parallel Sequencing
(Johns Hopkins University, 2015-03-24)
Worldwide, cancers remain a leading cause of death. The judicious use of cancer diagnostics -- broadly defined as tests for cancer -- has great potential to reduce disease morbidity and mortality. Impeding this potential ...
Flash NanoComplexation (FNC) as a Scalable and Tunable Platform for Anti-Cancer Drug/Gene Delivery
(Johns Hopkins University, 2018-05-15)
Nanoparticles (NPs) have been extensively investigated as drug carriers for the delivery of therapeutic agents and have demonstrated promising results in cancer treatment. However, the traditional NP preparation methods ...
The Role of the Secretory Pathway Ca2+-ATPase, SPCA2 in Breast Cancer Evolution
(Johns Hopkins University, 2018-03-27)
Calcium dysregulation in breast cancer can occur early during dysplasia in mammary tissue, and persist throughout the progression of cancer. This perturbation to the homeostasis of calcium can be detrimental to the normal ...
CANCER CELL MIGRATION AND DECISION-MAKING IN PHYSIOLOGICALLY RELEVANT CONFINING MICROENVIRONMENTS
(Johns Hopkins University, 2018-10-09)
In metastasis, cancer cells break away from a primary tumor and travel through the blood or lymph system to distant parts of the body forming new secondary metastatic tumors. Metastatic disease is responsible for ~90% of ...
ADVANCEMENTS IN GLYCOMETABOLIC ENGINEERING AND CARBOHYDRATE DRUG DESIGN
(Johns Hopkins University, 2018-04-16)
A near universal feature of virtually every major disease in humans has been the observation that proteins and lipids have perturbed patterns of glycosylation when compared to healthy tissues and cells, indicating that a ...
Cancer outcomes among people with HIV in North America in the era of antiretroviral therapy
(Johns Hopkins University, 2018-05-17)
Background: Poorer cancer outcomes have been observed for people with HIV (PWH) including more advanced stage at diagnosis, lower uptake of cancer treatment, and higher mortality. However, these results have not been ...
Development of Antibody Modulators for an Oncogenic Potassium Channel
(Johns Hopkins University, 2015-10-28)
Two-pore domain potassium (K2P) channels act to maintain cell resting membrane potential – a prerequisite for many biological processes. KCNK9, a member of K2P family, is implicated in cancer owing to its overexpression ...