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The Molecular Mechanism of HIV Entry
(Johns Hopkins University, 2014-03-26)
One of today’s greatest health challenges is stopping the spread of the Human Immunodeficiency Virus (HIV). HIV’s only surface protein is the envelope glycoprotein (Env), therefore Env is a major target for HIV intervention ...
A review of HIV restriction factors and viral countering mechanisms
(Johns Hopkins University, 2014-05-05)
Human immune system is powerful and it has evolved over the past thousands of years to protect us from various foreign pathogens. In fact, very few pathogens can threaten a man with a competent immune system. The notorious ...
THE IMPACT OF NUTRITIONAL AND INFLAMMATORY BIOMARKER LEVELS ON CD4 RECOVERY TO 96 WEEKS IN A TREATMENT-NAÏVE HIV-POSITIVE COHORT
(Johns Hopkins University, 2014-04-24)
Background
As antiretroviral therapy (ART) becomes more widespread globally, it is important to investigate factors which have an effect on HIV progression in order to determine the best intervention for individual patients. ...
HIV-1 Viral Infectivity Factor Recruitment of Cellular Protein Complexes to Counter Host Antiviral Response
(Johns Hopkins University, 2014-02-26)
Human cytidine deaminase apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) proteins (e.g. APOBEC3G) provide a potent host defense against HIV, in the absence of viral infectivity factor (Vif). ...
Healthcare Utilization among Persons Living with HIV with Attention to the Influences of Hepatitis Co-Infection and Elite Control
(Johns Hopkins University, 2015-04-01)
HIV infection has evolved from a consistently fatal diagnosis into a chronic condition that requires lifelong medication and care. These do not come cheaply. In 2015, the United States government is expected to spend $17.5 ...
THE CHANGING HIV EPIDEMIC IN THE MODERN ANTI-RETROVIRAL THERAPY ERA
(Johns Hopkins University, 2014-03-14)
During the early 21st century HIV underwent a transition from an invariably terminal illness to a manageable chronic condition. Much of this change is due to improvements in medication and management. Concurrently, treatment ...
BARRIERS TO SUCCESSFUL ENGAGEMENT IN CARE AMONG MEN WHO HAVE SEX WITH MEN IN MOSCOW, RUSSIA
(Johns Hopkins University, 2015-03-26)
Background: Globally, men who have sex with men (MSM) face a high and disproportionate burden of HIV infection. The framework of the HIV care continuum provides both an individual and population-based approach to addressing ...
Mobile Health (mHealth) Assessment of Illicit Drug Use Among Community Dwelling Drug Users in Baltimore, MD
(Johns Hopkins University, 2014-07-28)
Background: Substance abuse is a chronic disease often characterized by multiple attempts at abstinence, frequent relapse and is associated with a range of morbidities and mortality. This dissertation utilizes a mobile ...
Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe
(Johns Hopkins University, 2014-03-07)
Iron metabolism is very dynamic over the first year of life. Anemia is common in sub-Saharan African infants, particularly in the context of HIV infection. Hepcidin, a peptide hormone whose synthesis is simultaneously ...
CIGARETTE SMOKING BEHAVIORS AMONG PEOPLE LIVING WITH HIV: ASSOCIATIONS WITH INDIVIDUAL- AND SOCIAL-LEVEL CHARACTERISTICS
(Johns Hopkins University, 2013-09-20)
INTRODUCTION: Smoking is endemic among people with HIV and associated with morbidity and mortality. Little research has been conducted among smokers with HIV. Research has focused on examining individual-level characteristics ...