Search
Now showing items 1-10 of 12
VISCOSITY INDUCED CELLULAR ADAPTATIONS FOR INCREASED CELL MOTILITY
(Johns Hopkins University, 2020-05-12)
Cancer, a disease with significant dependence on genetic predisposition, is caused when an epithelial cell undergoes mutation and multiplies clonally in a direction away from the vascular supply to form a tumor. Cancer-related ...
EXPLORING CANCER PREVENTION AND SCREENING INFORMATION ENGAGEMENT ON FACEBOOK AMONG U.S. LATINOS
(Johns Hopkins University, 2020-04-09)
Latinos, the largest minority in the U.S., face a high burden of cancer, making it important to deliver evidence-based cancer prevention and screening information (CPSI) to them. Social media presents an innovative platform ...
MOLECULAR ANALYSIS OF CANCER PROGRESSION WITH LABEL-FREE RAMAN SPECTROSCOPY
(Johns Hopkins University, 2020-04-27)
Due to its ability to probe water-containing samples using visible and near-infrared frequencies with high chemical specificity, Raman spectroscopy is an attractive tool for label-free investigation of biological samples. ...
TARGETING CANCER MUTATIONS
(Johns Hopkins University, 2020-05-15)
If the first revolution of cancer research established the cellular basis of cancer, the second revolution defined its genetic basis. The past decade has seen astounding advances in our understanding of cancer genetics and ...
NEW ROLES FOR EXTRACELLULAR VESICLES AND DIGITAL PATHOLOGY IN STIFFNESS-MEDIATED CANCER PROGRESSION
(Johns Hopkins University, 2021-03-16)
An increase in extracellular matrix stiffness enhances cancer cell migration and proliferation at the primary tumor. While essential to our understanding of solid tumor progression, the study of cell and tissue mechanics ...
Fibronectin Mediates Cooperativity Between Subclonal Populations In Breast Cancer
(Johns Hopkins University, 2021-03-04)
Breast cancer was the most commonly diagnosed cancer in 2020 and the second leading cause of cancer mortality in women. Intratumor heterogeneity drives disease progression and therapeutic resistance and is a key contributor ...
Arsenic Exposure Induced Changes in MicroRNA Expression Levels in Urothelial Cells
(Johns Hopkins University, 2021-05-07)
Problem Statement: microRNAs (miRNAs) play an important role in regulating gene expression thereby controlling various pathological and physiological processes. miRNA dysregulation can cause chronic diseases like cardiovascular ...
ODORANT-SENSING RECEPTORS IN CANCER PROGRESSION: UNCOVERING THE FORBIDDEN PERCEPTIONS IN CANCER CELL MIGRATION
(Johns Hopkins University, 2021-04-14)
G protein-coupled receptors (GPCRs), a class of cell surface receptors with 7 transmembrane spanning domains, are master regulators of human physiology and currently make up ~40% of all therapeutic targets. However, few ...
CARD11 DISEASE ASSOCIATED MUTATIONS AND THEIR EFFECTS ON IMMUNITY AND LYMPHOMA
(Johns Hopkins University, 2021-09-09)
The antigen receptors of lymphocytes are coupled to signaling pathways which are essential for B cells and T cells to mediate the adaptive immune response. CARD11 is a crucial adaptor protein in antigen receptor-signaling ...
Roles of TFE3 Fusion Oncoprotein Condensates in Renal Cell Carcinoma
(Johns Hopkins University, 2022-05-09)
TFE3 fusion Renal Cell Carcinoma is a type of Renal Cell Carcinoma that is caused by genome rearrangements. In TFE3 fusion renal cell carcinoma, the TFE3 transcription factor is fused with other proteins, leading to formation ...