Now showing items 1-6 of 6
A Fc Domain-Conjugated Adenosine 2A Receptor Ligand for Immune Checkpoint Blockade
(Johns Hopkins University, 2016-09-28)
In light of the recent success of immune checkpoint blockade in cancer treatments, new inhibitory molecules and pathways have been increasingly considered as targets for cancer immunotherapy. The adenosine A2A receptor has ...
RELEASING THE BRAKES: STRATEGIES TO REMODEL THE TUMOR ENVIRONMENT, INCREASE IMMUNE INFILTRATE, AND INDUCE TUMOR CELL DEATH
(Johns Hopkins University, 2016-07-21)
The tumor immune infiltrate and tumor cytokine microenvironment have been shown to be crucially important to patient responses to immunotherapy. The presence of effector T cells in the tumor correlates highly with good ...
Asymptomatic P. vivax Malaria Burden and Naturally-Acquired Humoral Response to PvMSP1-19 in a Low Endemic Malaria Area in the Peruvian Amazon Basin
(Johns Hopkins University, 2016-01-13)
Objective: P. vivax (Pv) malaria is the most widely distributed human malaria species in the world, affecting millions of people annually, and the most prevalent species in the Americas. One of the main challenges for the ...
METABOLIC ALTERATIONS IN AIRWAY EPITHELIUM IN ALLERGIC ASTHMA
(Johns Hopkins University, 2016-07-27)
Allergic asthma is a chronic inflammatory disease of the lung. It is thought to arise as a result of aberrant type-2 immune responses to environmental allergens in susceptible individuals. Among the allergens, sensitization ...
TH2 T CELLS ARE REQUIRED FOR BIOMATERIAL-MEDIATED FUNCTIONAL MUSCLE REGENERATION
(Johns Hopkins University, 2016-03-21)
Regenerative medicine therapies that primarily target stem cells have achieved limited success. An alternative strategy is to focus on immune cells, the first responders to traumatic wounds, which can interact directly ...
Detection of Measles Virus RNA in Lymph Nodes Using Fluorescence Microscopy
(Johns Hopkins University, 2016-04-22)
Measles is a highly infectious viral disease that typically occurs in childhood. Upon infection, it results in a high fever, runny nose, red and watery eyes and a characteristic rash that covers the entire body and lasts ...