Now showing items 1-6 of 6
GENOME-WIDE STUDIES ON POST-TRANSCRIPTIONAL REGULATION
(Johns Hopkins University, 2016-06-08)
Regulation of gene expression is essential for cellular survival and complex responses or phenotypes. Improvements in sequencing technology enable investigation of RNA transcription as a means to understand complex biological ...
Elucidating genetic determinants of heart disease and longevity through genome-wide association analyses
(Johns Hopkins University, 2016-11-07)
The research described in this dissertation consists of three projects. In the first, I investigate of the impact of genome-wide heterozygosity on overall longevity in humans and estimate that within a single population, ...
Sparsity and scarcity: Multiomic studies in a low resource setting (A study in archival FFPE cancer tissue)
(Johns Hopkins University, 2016-11-29)
Archival formalin-fixed, paraffin-embedded (FFPE) tissues are an invaluable resource for biomarker discovery due to their vast number in pathology laboratories and availability of high-quality, long-term clinical information. ...
WHAT COUNTS? THE ROLE OF NUMERACY IN INTERPRETATION OF PERSONALIZED GENOMIC RISK INFORMATION IN CORIELL PARTICIPANTS
(Johns Hopkins University, 2016-02-01)
Purpose To investigate how numeracy influences personalized genomic risk interpretation using objective risk estimates, affective risk ratings, and genetic self-efficacy. Methods A one-time, 2x2 between-subjects survey ...
Personal Utility in Genomics: A Mixed-Methods Study to Identify Key Elements
(Johns Hopkins University, 2016-01-27)
Background: With the rapid integration of new sequencing technologies, researchers and clinicians recognize how genomic test results affect recipients in ways distinct from generally accepted clinical outcomes. These ...
Annotation-Agnostic Differential Expression and Binding Analyses
(Johns Hopkins University, 2016-07-25)
My thesis work is centered around the development of R software packages for analyzing RNA sequencing (RNA-seq) and ChIP sequencing (ChIP-seq) high throughput genomic data. Chapter 2 describes the derfinder Bioconductor package ...