Now showing items 1-5 of 5
The Topology, Regulation, and Function of Cardiolipin Remodeling in Saccharomyces cerevisiae
(Johns Hopkins University, 2014-04-29)
Cardiolipin (CL) is a unique phospholipid that resides exclusively within mitochondria, and is required for the optimal function of numerous mitochondrial processes. After synthesis, CL undergoes an evolutionarily conserved ...
THE ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR 2 OVEREXPRESSION ON ATTENUATING REACTIVE OXYGEN SPECIES IN THE HEART
(Johns Hopkins University, 2014-06-09)
Current statistics for the incidence of breast cancer reveal that it is the most common form of cancer and leading cause of death from cancer among women worldwide. In the US, breast cancer follows lung cancer as the second ...
Role of Mitochondria in Cardiac Arrhythmias
(Johns Hopkins University, 2013-10-11)
Mitochondria are the major organelles responsible for providing energy to the cardiac myocytes. In ischemic conditions, the supply of nutrients and oxygen to a region of the heart, or the whole organ, is interrupted. ...
CYTOSOLIC PROTEIN INTERACTION WITH THE VOLTAGE DEPENDENT ANION CHANNEL OF THE MITOCHONDRIAL OUTER MEMBRANE CONTROLS CELLULAR RESPIRATION
(Johns Hopkins University, 2014-02-03)
The voltage dependent anion channel (VDAC) is a beta-barrel protein that spans the mitochondrial outer membrane and serves as the passageway for the flux of metabolites responsible for mitochondrial function. It was ...
ON THE CONTRIBUTION OF SELF-MEDIATED ORGANIZATION OF KERATIN INTERMEDIATE FILAMENTS TO THEIR BIOLOGICAL FUNCTION IN VIVO
(Johns Hopkins University, 2014-04-17)
The crucial role of structural support fulfilled by keratin intermediate filaments (IFs) in surface epithelia likely requires that they be organized into crosslinked networks. For IFs comprised of keratins 5 and 14, found ...