Now showing items 1-4 of 4
ONCOGENIC PROPERTIES AND TARGETING OF NTRK1 IN BREAST CANCER
(Johns Hopkins University, 2018-03-23)
Triple negative breast cancers (TNBC) comprise a highly aggressive cancer subtype with high mortality rates, high frequency of metastatic disease and a lack of targeted therapies. A fraction of these cancers also demonstrate ...
The Role of the Secretory Pathway Ca2+-ATPase, SPCA2 in Breast Cancer Evolution
(Johns Hopkins University, 2018-03-27)
Calcium dysregulation in breast cancer can occur early during dysplasia in mammary tissue, and persist throughout the progression of cancer. This perturbation to the homeostasis of calcium can be detrimental to the normal ...
ADVANCEMENTS IN GLYCOMETABOLIC ENGINEERING AND CARBOHYDRATE DRUG DESIGN
(Johns Hopkins University, 2018-04-16)
A near universal feature of virtually every major disease in humans has been the observation that proteins and lipids have perturbed patterns of glycosylation when compared to healthy tissues and cells, indicating that a ...
EARLY-STAGE BREAST CARCINOMA MECHANICALLY REMODELS THE TUMOR MICROENVIRONMENT TO PROMOTE CANCER PROGRESSION
(Johns Hopkins University, 2018-05-09)
The remodeling of the tumor microenvironment is a characteristic behavior that malignant tumors utilize to progress towards late stages of cancer. Though this has been observed in in vivo studies, the measurement of tumor ...