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Detection of PIK3CA Mutations in Plasma Tumor DNA Circulating in Peripheral Blood of Breast Cancer Patients
(Johns Hopkins University, 2014-04-10)
Tumor-specific mutations are used as genetic biomarkers for breast cancer
diagnosis and prognosis. The detection and quantification of mutations in tumor DNA
circulating in peripheral blood offers a non-invasive approach ...
Synthesizing Data Sources to Develop and Update Risk Models
(Johns Hopkins University, 2014-06-19)
Building risk models from multiple different sources of data allows researchers to incorporate the best available information on key model parameters. In this thesis, we develop and apply methodology for optimally combining ...
Steady-state Susceptibility Contrast MRI of Breast Cancer Angiogenesis: Preclinical Validation and Application
(Johns Hopkins University, 2014-02-07)
Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...