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The Role of the Secretory Pathway Ca2+-ATPase, SPCA2 in Breast Cancer Evolution

Dang, Donna K (Johns Hopkins University, 2018-03-27)

Calcium dysregulation in breast cancer can occur early during dysplasia in mammary tissue, and persist throughout the progression of cancer. This perturbation to the homeostasis of calcium can be detrimental to the normal ...

CALCIUM AT THE PUMP: REGULATION OF INTRACELLULAR CALCIUM BY SECRETORY PATHWAY CALCIUM ATPASE ISOFORM 2 (SPCA2) IN MODELS OF LACTATION AND BREAST CANCER

Cross, Brandie Makeba (Johns Hopkins University, 2013-09-06)

Secretory Pathways Calcium ATPase 2 (SPCA2) is a non-redundant isoform of SPCA expressed in highly secretory cells. In this study we aimed to investigate physiological regulation of SPCA2 as a possible regulator of calcium ...