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Cancer-Associated Isocitrate Dehydrogenase Mutation: Structural Basis of Enzyme Inactivation
(Johns Hopkins University, 2014-01-09)
Isocitrate dehydrogenase enzymes catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate. Somatic point mutations in the IDH1 gene are observed in glioblastoma multiforme and acute myeloid leukemia, with a ...