Theses and Dissertations, Electronic (ETDs): Recent submissions
Now showing items 1-20 of 6976
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Aged Tumor Microenvironment Promotes Elevated Autophagy in Cutaneous Melanoma
(Johns Hopkins UniversityUSA, 2022-12-16)Deadliest of all skin cancers, melanoma is highly metastatic and markedly resistant to modern therapies. Age-adjusted incidence rates of melanoma have risen 1.2% each year over the last decade, whereas death rates have ... -
EXPLORING GENETIC COUNSELORS’ USE OF TUMOR SEQUENCING TO IDENTIFY GERMLINE VARIANTS: TIME FOR A CHANGE IN SCOPE?
(Johns Hopkins UniversityUSA, 2022-12-14)Objective: Tumor sequencing (TS) is used by most oncologists for precision treatment 1-4, and has now been found to reveal potential germline cancer predisposition variants (PGCVs) in ~12-14% of cases 5-7. Reviewing TS ... -
CHARACTERIZING DECISION-MAKING SURROUNDING EXERCISE IN ARVC: ANALYSIS OF DECISIONAL CONFLICT, DECISIONAL REGRET, AND SHARED DECISION-MAKING
(Johns Hopkins UniversityUSA, 2022-12-13)Background: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic condition that predisposes individuals to arrythmia, cardiomyopathy, and sudden cardiac death (SCD). Because of associated risk, it is recommended ... -
Reproductive Decision-Making for X-linked Heterozygotes: Unexplored Complexities
(Johns Hopkins UniversityUSA, 2022-12-12)Background: Reproductive decision-making (RDM) is known to be a complex process, especially for heterozygotes with a pathogenic X-linked genetic variant. While studies of carriers of genetic conditions with various ... -
MODELING THE EFFECTS OF SURVEY TIMING ON SCORES FOR THE WORKING ALLIANCE INVENTORY IN A SECONDARY DATA ANALYSIS OF CARDIOVASCULAR GENETIC COUNSELING OUTCOMES
(Johns Hopkins UniversityUSA, 2022-12-12)Genetic counseling (GC) research has increasingly regarded the therapeutic alliance, often assessed with the Working Alliance Inventory – Short Revised (WAI-SR), as a variable through which GC outcomes may be mediated. In ... -
Investigation of Volatile Organic Compounds Emissions in Different Stages of HVAC System
(Johns Hopkins UniversityUSA, 2022-08-22)Efficient heating, ventilating, and air-conditioning (HVAC) systems are essential for improving indoor air quality and human health. However, HVAC systems those days typically rely on mechanical ventilation and filters to ... -
Seq2Seq Scene Graph Generation Utilizing Vision-language Pretrained Model
(Johns Hopkins UniversityUSA, 2022-12-20)Scene graph generation (SGG) aims to represent a visual scene with a hierarchical structure that contains objects, attributes and relationships. Most existing SGG methods require two stages for detecting objects and ... -
Computational Analysis of 3d Cleared and Labeled Pancreatic Cancer Samples
(Johns Hopkins UniversityUSA, 2022-12-12)Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pan- creatic cancer and with a 5-year survival rate of only 11%, it is amongst the deadliest cancers. Understanding pancreatic cancer growth pattern on a ... -
BAYESIAN APPROACH TO MODELING THE RESPONSE OF A PATIENT TO DRUG TREATMENT
(Johns Hopkins UniversityUSA, 2022-12-13)Drug viability is an important driver in determining the success of treatment. Developing customized treatment means developing a model for the patient. In this work, we use Hill's Equation to model a drug’s viability as ... -
ELECTROCHEMICALLY TUNABLE TWO-DIMENSIONAL MEMBRANES FOR IONIC AND MOLECULAR SIEVING
(Johns Hopkins UniversityUSA, 2022-12-09)Purifying mixtures is still a tough objection currently. Conventional separation processes based on thermal or chemical methods would higher global energy consumption and pollution emission. Hence, alternative routes need ... -
Antifungal Drug Formulation for Vaginal Yeast Infection
(Johns Hopkins UniversityUSA, 2022-12-09)Over 138 million women worldwide are affected by recurrent yeast vaginitis or Candidiasis [1]. Candidiasis is a type of infection caused by yeast Candida albicans overgrowth, and it is one of the most common diseases ... -
Solving Complex Geometry Kinematics Problem with Function Approximation by Artificial Neural Network
(Johns Hopkins UniversityUSA, 2022-12-09)Neural networks have been widely deployed to solve classification and regression problems, and, in recent years, there has been much interest in using neural networks for solving complicated problems. In this paper, a ... -
Soluble lymphocyte activation gene-3 contributes to α-synucleinopathy and related therapeutic development
(Johns Hopkins UniversityUSA, 2022-12-09)Pathogenetic α-synuclein (α-Syn) misfolded preformed fibrils (PFF) in Parkinson’s disease (PD) spreads from cell-to-cell in a prion-like manner has been evident in many studies. However, the spreading mechanism remains ... -
Investigation into Subcutaneous Injection Modeling
(Johns Hopkins UniversityUSA, 2022-12-09)Clinical and animal models for subcutaneous injections can be expensive and inaccurate. In vitro models offer a more convenient and inexpensive way to test for drug bioavailability after administration. Subcutaneous Injection ... -
IN VIVO BIOMECHANICAL STRAIN RESPONSE OF THE LAMINA CRIBROSA TO INTRAOCULAR PRESSURE CHANGE AS A RESULT OF GLAUCOMA MEDICATION CHANGE
(Johns Hopkins UniversityUSA, 2022-12-08)The aim of the present pilot study was to evaluate the feasibility of a method for characterizing the short-term, in vivo biomechanical response of the lamina cribrosa (LC) in the eyes of patients starting glaucoma medication ... -
SUBUNIT PEPTIDE-ENCAPSULATING NANOPARTICLE HIV VACCINE TARGETING CYTOTOXIC T LYMPHOCYTE ACTIVATION VIA PROTAC-ENHANCED CROSS PRESENTATION
(Johns Hopkins UniversityUSA, 2022-12-09)Development of an effective prophylactic vaccine against HIV remains an ongoing challenge. Protein subunit vaccines have garnered interest recently, due to desirable safety and stability profiles in comparison to whole-pathogen ... -
Simulation and Modeling for UHR-MDCT and Photon-Counting CT
(Johns Hopkins UniversityUSA, 2022-12-08)New CT technologies, such as ultra-high resolution multi-detector CT (UHR-MDCT), and photon-counting CT, open the potential for visualizing bone microarchitecture and enables material decomposition with a single scan. ... -
LEAD CHALCOGENIDE QUANTUM DOT ASSEMBLY AND ATTACHMENT ON FLUID INTERFACES
(Johns Hopkins UniversityUSA, 2022-12-09)The formation of tiles composed of quantum dots is thought to constitute a new class of self- assembled nanostructured material. Understanding the dynamic physicochemical processes that govern the assembly at a functionalized ... -
iPSC DERIVED CARDIOMYOCYTE MATURATION AND CRYOPRESERVATION
(Johns Hopkins UniversityUSA, 2022-12-09)The development of induced pluripotent stem cell (iPSC) technology has revolutionized biomedical research and the study of modern medicine. iPSCs, like their embryonic counterparts, can differentiate into the three germ ... -
Simulation-Based Optimization with Constrained SPSA for Water Distribution Networks on Military Installations
(Johns Hopkins UniversityUSA, 2022-12-08)The purpose of this paper is to combine simulation-based optimization and simultaneous perturbation stochastic approximation (SPSA) to create an effective model of a water distribution network and return the optimal diameters ...