Now showing items 2547-2566 of 4843

    • m6A mRNA METHYLATION IN DEVELOPMENT AND DISEASE 

      Vissers, Caroline; 0000-0002-9888-8516 (Johns Hopkins UniversityUSA, 2019-12-18)
      Chemical modifications on mRNA have recently garnered attention as major regulators of cell behavior in embryonic development and many types of disease. In particular, N6-adenosine (m6A), is an abundant mRNA modification ...
    • MACHINE LEARNING AND COMPUTATIONAL CARDIAC MODELING FOR CLINICAL DECISION SUPPORT IN PATIENTS WITH CARDIOVASCULAR DISEASE 

      Shade, Julie Kristin; 0000-0002-4510-2516 (Johns Hopkins UniversityUSA, 2021-09-30)
      Cardiovascular diseases are the leading cause of mortality around the world. Many of these deaths result from abnormal heart rhythms, or arrhythmias, including ventricular tachycardia (VT) and atrial fibrillation (AF). ...
    • MACHINE LEARNING AND OPTIMIZATION FOR HEALTHCARE AND ENERGY SYSTEMS 

      Jiang, Wei (Johns Hopkins UniversityUSA, 2018-05-11)
      Healthcare and energy systems provide critical service to our society. Recent advancement in information technology has enabled these systems to keep retrieving and storing data. In this dissertation, we used machine ...
    • Machine Learning Attacks on Optical Physical Unclonable Functions 

      Atakhodjaev, Iskandar (Johns Hopkins UniversityUSA, 2018-08-28)
      Traditional security algorithms for authentication and encryption rely heavily on the digital storage of secret information (e.g. cryptographic key), which is vulnerable to copying and destruction. An attractive alternative ...
    • Machine Learning for Beamforming in Audio, Ultrasound, and Radar 

      Nair, Arun Asokan; 0000-0002-6857-4313 (Johns Hopkins UniversityUSA, 2021-07-14)
      Multi-sensor signal processing plays a crucial role in the working of several everyday technologies, from correctly understanding speech on smart home devices to ensuring aircraft fly safely. A specific type of multi-sensor ...
    • Machine Learning for Individualized Clinical Risk Prediction and Prevention 

      Wongvibulsin, Shannon (Johns Hopkins UniversityUSA, 2019-03-19)
      The rising burden of healthcare costs suggests that the healthcare system could benefit from novel methods that allow for continuous learning to provide more individualized care at lower costs and with improved outcomes. ...
    • MACHINERIES FOR COMPUTATIONAL STUDIES ON PLASTICITY IN AMORPHOUS SOLIDS AND HOMOGENEOUS NUCLEATION IN INTERMETALLIC COMPOUNDS 

      Ruan, Dihui; 0000-0001-8964-730X (Johns Hopkins UniversityUSA, 2021-06-17)
      Atomistic simulations enjoy wide applications in inorganic compounds, metals, polymers, biomacromolecules and other areas of materials science. Such simulations have been used extensively to study microstructure-property ...
    • Macrocyclic Probes For Cell Adhesion And The Unfolded Protein Response 

      Sanchez, Phillip Raul (Johns Hopkins UniversityUSA, 2020-01-10)
      This thesis covers the discovery and development of two small-molecule compounds F10 and Superstolide/ZJ-101 with unknown targets and mechanisms-of-action. Screening of the Rapafucin library for Unfolded Protein Response ...
    • Macromolecular Studies of the Dynamic Structure and Mechanical Properties of the Endothelial Surface Layer 

      Danova-Okpetu, Darina (Johns Hopkins University, 2006-08-03)
      The endothelial surface layer (ESL) is a micron-scale macromolecular lining of the luminal side of blood vessels, composed of proteoglycans, glycoproteins, polysaccharides and plasma proteins in dynamic equilibrium. Its ...
    • MACROPHAGES: AN OVERLOOKED LATENT VIRAL RESERVOIR IN SIV INFECTION 

      Avalos, Claudia Regina; 0000-0003-1774-894X (Johns Hopkins UniversityUSA, 2016-07-14)
      HIV infection remains a worldwide epidemic without prospects of a cure. While antiretroviral therapy (ART) successfully decreases plasma viral load and prevents new cells from becoming infected, long-lived latently infected ...
    • Magnetic Fields in Astrophysical Environments 

      Jafari Alanjagh, Amir; 0000-0003-3370-105X (Johns Hopkins UniversityUSA, 2018-01-30)
      We consider stochastic magnetic reconnection in high β plasmas with a large ratio of kinematic viscosity to magnetic diffusivity. Previous work has shown that stochastic reconnection can yield speeds comparable to the large ...
    • Magnetic Resonance Imaging and Spectroscopy Biomarkers in Hereditary Muscle Diseases 

      Leung, Doris Gay Yee; 0000-0002-2558-7798 (Johns Hopkins UniversityUSA, 2016-10-24)
      Statement of problem: Clinical research in hereditary muscle disease is limited by the absence of quantitative and objective biomarkers and outcome measures that track disease severity. A growing body of literature supports ...
    • MAGNETIC RESONANCE IMAGING OF CEREBRAL VENOUS OXYGENATION 

      Jiang, Dengrong (Johns Hopkins UniversityUSA, 2019-11-19)
      Cerebral venous oxygenation (Yv) is an important index of the brain’s oxygen metabolism, and has found clinical utility in various diseases, such as multiple sclerosis and Alzheimer’s disease. Traditionally, positron ...
    • MAGNETIC RESONANCE IMAGING OF CEREBROVASCULAR REACTIVITY 

      Hou, Xirui (Johns Hopkins UniversityUSA, 2021-12-20)
      Cerebrovascular reactivity (CVR) is an important indicator of cerebrovascular reserve and provides important information about vascular health in a range of brain conditions and diseases. Unlike steady-state vascular ...
    • Magnetism near the Electron Localization Transition 

      Wu, Shan (Johns Hopkins UniversityUSA, 2017-07-23)
      An emergent property of interaction electrons in solids, magnetism is closely tied to electron localization. The transition from localized (insulating) to itinerant (conducting) electronic states consequently marks a ...
    • Magneto Terahertz Response of Topological Materials 

      Cheng, Bing (Johns Hopkins UniversityUSA, 2019-10-03)
      In this thesis, I have used time-domain magneto terahertz spectroscopy to study several topological materials including topological insulator single crys- tals of Bi0.1Sb0.9Te2S, topological crystalline insulator thin films ...
    • Makeshift Solutions: Serial Poetry and Secular Stagnation, 1965 to Today 

      Westcott, Christopher (Johns Hopkins UniversityUSA, 2017-08-23)
      “Makeshift Solutions: Serial Poetry and Secular Stagnation, 1965 to Today” tells a story about poetry and imaginative prose patterned in ways commonly described as serial. It is also a story about value, both as a category ...
    • Making and Remaking the Market: Government Intervention in the LNG Market in Japan and the Republic of Korea 

      Choi, Jeanne Kim (Johns Hopkins UniversityUSA, 2022-08-31)
      This dissertation traces the development of the liquefied natural gas (LNG) market in Japan and the Republic of Korea (Korea). The study begins with the establishment of the domestic market, with the first imports of the ...
    • Making Care Safer: Exploring Predictors and Impact of RN Burnout and Engagement 

      Mossburg, Sarah Elizabeth; 0000-0003-4260-8084 (Johns Hopkins UniversityUSA, 2018-07-18)
      Background During the last two decades of the patient safety movement, healthcare has made much progress. Yet evidence suggests that there remains a long path forward. A 2016 study ranked deaths due to medical error as the ...
    • Making Culture, Moving Margins: Cultural Policy and State-Society Relations in Brazil 

      Gillman, Anne (Johns Hopkins UniversityUSA, 2017-06-15)
      Even under many putatively democratic governments, large swaths of the citizenry experience alienation from states with uneven presence throughout the national territory. Yet while political scientists have examined why ...