Browsing ETD -- Doctoral Dissertations by Title
Now showing items 947-966 of 4630
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D1 AND D2 DOPAMINE RECEPTOR BIASED AND HETEROMERIC SIGNALING: IMPLICATIONS FOR PROTEIN CONFORMATIONAL FLUIDITY
(Johns Hopkins UniversityUSA, 2015-08-24)The D1R and D2R dopamine receptor (DAR) subtypes represent the two most abundant and highly targeted DARs, but the precise mechanisms of drug action at the molecular level are not well understood. A revolution in the ... -
DARK NOISE AND THE APO-OPSIN EFFECT IN RETINAL RODS AND CONES
(Johns Hopkins UniversityUSA, 2018-11-01)Our visual system is exceedingly complex, but initiating light detection requires only a small number of reactions in retinal rods and cones. In the first stages of vision, the exact nature of signal amplification and ... -
Dark Z' Search and (Un)Natural Supersymmetric Models
(Johns Hopkins University, 2014-08-26)The Standard Model (SM) of particle physics is the most successful theory of particles and fundamental laws of nature. It has been tested numerous times for over forty years. Yet, it is considered to be incomplete. It does ... -
Data Assimilation in Wall Turbulence
(Johns Hopkins UniversityUSA, 2021-12-17)Starting from limited observations of wall turbulence, data assimilation attempts to reconstruct fully-resolved instantaneous fields that satisfy the Navier-Stokes equations. These inverse problems are challenging due to ... -
Data Fusion at Scale in Astronomy
(Johns Hopkins UniversityUSA, 2017-10-26)We have arrived in an era where we face a deluge of data streaming in from countless sources and across virtually all disciplines; This holds especially true for data intensive sciences such as astronomy where upcoming ... -
Data Fusion via Manifold Matching
(Johns Hopkins University, 2013-10-23)Data fusion has been an interesting and challenging research topic, which receives intensive investigation in many areas. The theory and practice of data fusion - the integration of information from disparate sources - are ... -
DATA REDUCTION FOR THE CLASS EXPERIMENT AND LIMITS ON SPECTRAL INDEX VARIATIONS IN THE POLARIZED DUST FOREGROUND
(Johns Hopkins UniversityUSA, 2021-08-16)One of the major goals in cosmology today is the detection of primordial gravitational waves in the Cosmic Microwave Background (CMB) polarization. This detection would be a confirmation of inflation and significantly tighten ... -
DATA-DRIVEN AND KNOWLEDGE-DRIVEN COMPUTATIONAL MODELS OF ANGIOGENESIS IN APPLICATION TO PERIPHERAL ARTERIAL DISEASE
(Johns Hopkins University, 2015-03-24)Angiogenesis, the formation of new blood vessels from pre-existing vessels, is involved in both physiological conditions (e.g. development, wound healing and exercise) and diseases (e.g. cancer, age-related macular ... -
Data-Driven Representation, Learning and Applications: From Compressed Sensing to Deep Neural Networks
(Johns Hopkins UniversityUSA, 2017-10-23)As the development of high-density sensors, the compressed sensing (CS) and sparse representation have been successfully implemented for building power-efficient systems by reducing sampling, transmission bandwidth and ... -
DE NOVO ENGINEERING OF CHEMOTACTIC TRANSDUCTION IN CELLS & CELL-MIMETIC DEVICES
(Johns Hopkins UniversityUSA, 2018-03-27)Spatiotemporal regulation of signaling is an integral feature of biologicalnetworks. Cellular processes driven by membrane-localized forces are prevalentand crucial in both health and disease. These include cell division, ... -
De novo genome assembly and analysis of non-allelic recombination in pathogenic yeast Candida glabrata
(Johns Hopkins UniversityUSA, 2019-12-02)Candida glabrata is an opportunistic pathogen in humans, responsible for approximately 20% of disseminated candidiasis. C. glabrata’s ability to adhere to host tissue is mediated by GPI-anchored cell wall proteins (GPI-CWPs); ... -
DEA VIRTUS: MARTIAL GLORY AS DIVINITY IN THE LITERARY AND VISUAL CULTURE OF ANCIENT ROME
(Johns Hopkins UniversityUSA, 2020-10-29)The Roman goddess Virtus has long been enshrouded in mystery from her cult to her image. Originally an ethical quality meaning “manliness,” virtus was deified during the Republic by the general Marcellus, who vowed to ... -
DEAR LANDLORD: HOW THE OWNERSHIP AND MANAGEMNT OF RENTAL PROPERTIES IN BALTIMORE, DALLAS, AND CLEVELAND MATTER FOR TENANTS, NEIGHBORHOODS, AND THE CITY
(Johns Hopkins UniversityUSA, 2018-07-06)The strategies, resources, choices, ideologies, and identities of rental property owners are of enormous consequence for poor families and urban development. While frequently studied in the aggregate, little research has ... -
Decamerons Without Women: The Spiritualization of Italian Literature in the Sixteenth and Seventeenth Centuries
(Johns Hopkins UniversityUSA, 2017-05-02)This dissertation takes Francesco Dionigi da Fano’s 1594 Decamerone Spirituale as the prime example of the many ‘spiritualizations’ of classics of Italian literature in the sixteenth and seventeenth centuries. The author, ... -
Decentralized Anonymous Payments
(Johns Hopkins UniversityUSA, 2017-08-31)Decentralized payment systems such as Bitcoin record monetary transactions between pseudonyms in an append-only ledger known as a blockchain. Because the ledger is public, permanent, and readable by anyone, a user’s privacy ... -
DECIPHERING GENETICS OF GENE EXPRESSION AND CHROMATIN ACCESSIBILITY VIA INTEGRATION OF LARGE-SCALE GENOMIC DATA
(Johns Hopkins UniversityUSA, 2021-07-26)Understanding the impact of genetic mutations on complex phenotypes is essential towards understanding human phenotypes including diseases. Capturing the genetic regulation on gene expression and on epigenetic signatures ... -
Deciphering Intracellular Signaling Regulating Directed Cell Migration
(Johns Hopkins University, 2013-10-18)Directed cell migration is a ubiquitous phenomenon with implications in development, wound healing, immunity, and metastasis. The ability of cells to orient their migration is dependent on the presence of external cues, ... -
DECIPHERING THE BIOCHEMICAL INTERACTIONS OF THE MECHANORESPONSIVE CONTRACTILITY CONTROLLER
(Johns Hopkins UniversityUSA, 2020-01-30)Every biological process, ranging from cell migration to embryogenesis, relies on the cell’s ability to adapt to changing mechanical environments. Cellular contractility is governed by a control system of proteins that ... -
DECIPHERING THE ROLE OF DNMT3B IN REGULATING DNA METHYLATION AND EPIGENETIC MODULATION OF TRANSCRIPTIONAL SILENCING
(Johns Hopkins UniversityUSA, 2014-07-02)DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. DNA methylation patterns are not randomly distributed, instead they are compartmentalized by region. In normal cells ... -
Deciphering the substrate selectivity of a rhomboid enzyme to design RiBn, a PfROM4-selective inhibitor that blocks invasion and clears blood-stage malaria
(Johns Hopkins UniversityUSA, 2018-03-22)The rhomboid family of intramembrane serine proteases have been implicated in critical parasite functions such as immune evasion, host-cell attachment, and, in the case of ROM4 from Plasmodium falciparum, invasion. Because ...