Browsing ETD -- Doctoral Dissertations by Title
Now showing items 3841-3860 of 4630
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T Cell Effector Responses in HIV-1 Cure Strategies
(Johns Hopkins UniversityUSA, 2016-05-12)HIV-1 is a virus that affects over 35 million individuals around the world, and yet despite present treatments, there remains a need for a cure. A current cure tactic widely researched is the “shock and kill” strategy, ... -
Tackling viscoelastic turbulence
(Johns Hopkins UniversityUSA, 2018-02-26)Turbulence in viscoelastic flows is a fascinating phenomenon with important technological implications, e.g. drag reduction at high Reynolds numbers and increased mixing efficiencies at low Reynolds numbers. The dynamics ... -
Tactile Perception of Three-Dimensional Shapes
(Johns Hopkins UniversityUSA, 2015-07-15)Previous studies of three-dimensional shape perception showed that the tactile system is capable of perceiving a wide variety of shapes, ranging from small objects touched by a single finger to large objects touched by ... -
TACTILE PROCESSING DEPENDS ON MOTOR INTENTIONS
(Johns Hopkins UniversityUSA, 2019-06-06)Tactile processing serves upcoming actions, which depend on behavioral goals. It remains unclear how neural signals related to movements interact with sensory signals in primary somatosensory (S1) cortex. We developed a ... -
Tailored Immunosuppression for Kidney Transplant Recipients
(Johns Hopkins UniversityUSA, 2020-04-02)In certain subgroups of kidney transplant (KT) recipients, early steroid withdrawal (ESW) may lower the risk of adverse effects while only minimally increasing the risk of acute rejection or graft failure. Anecdotally, ... -
Tailoring services to promote family economic self-sufficiency and continued enrollment in maternal and early childhood home visiting programs
(Johns Hopkins UniversityUSA, 2018-04-11)Objectives: Many families and young children enrolled in home visiting (HV) experience health and social benefits, but HV programs often have difficulty retaining families in services. HV provides services to diverse ... -
Tailoring the mechanical behavior of nanocrystalline thin films with alloying and heat treatments
(Johns Hopkins UniversityUSA, 2016-03-18)Metals and alloys with grain sizes below a hundred nanometers exhibit very different mechanical and physical properties compared to their coarse grained counterparts. Unique nanoscale deformation mechanisms are triggered ... -
The Tails of Two Histones: It was an old histone, it was a new histone
(Johns Hopkins University, 2014-03-23)The basis of multi-cellular systems relies on different cell types performing different roles for a properly functioning organism. However, these cells need to express different sets of genes in order to maintain their ... -
TAKE IT TO THE SEA: NONMILITARY ACTORS IN CHINA’S MARITIME DISPUTES AND CRISIS MANAGEMENT
(Johns Hopkins UniversityUSA, 2021-07-13)Two decades into the 21st century, China still faces a plethora of unsettled territorial and boundary disputes on its maritime frontier spanning from the Yellow Sea, East China Sea, and the South China Sea. These disputes ... -
Taking the Helm: Genealogical Debunking Arguments, Moral Realism, and the Possibility of Moral Knowledge
(Johns Hopkins UniversityUSA, 2019-04-24)Genealogical debunking arguments aim to show that, given their provenance, none of our moral beliefs are justified, at least assuming moral realism. In particular, they claim that this is so because the best, complete ... -
Tales from the Crypto: Phagolysosomal Phenomena Featuring Fungi
(Johns Hopkins UniversityUSA, 2020-06-02)Host-pathogen interactions are a cornerstone of microbiology and medicinal research. Many incredible cellular mechanisms evolved from arms races between pathogens and host defenses. Studying these mechanisms leads to ... -
TALKING TO WOMEN, ADVISING MEN: THE FEMALE ELDERLY ADVISOR IN LATE MEDIEVAL AND RENAISSANCE ITALIAN LITERATURE
(Johns Hopkins UniversityUSA, 2020-07-08)This project analyzes depictions of elderly advisors who counsel younger women on love and men in Italian literature from the late Middle Ages to the Renaissance My goal is to demonstrate how the character of the old woman ... -
Taming Big Data By Streaming
(Johns Hopkins UniversityUSA, 2017-10-09)Data streams have emerged as a natural computational model for numerous applications of big data processing. In this model, algorithms are assumed to have access to a limited amount of memory and can only make a single ... -
Targeted Cytosine Methylation using dCas9- methyltransferases
(Johns Hopkins UniversityUSA, 2017-10-20)Mammalian genomes exhibit complex patterns of gene expression regulated, in part, by DNA methylation. The advent of engineered DNA methyltransferases (MTases) to target DNA methylation to specific sites in the genome will ... -
Targeting bifurcated methyltransferases towards user-defined DNA sequences
(Johns Hopkins University, 2014-02-21)There would be great value in targeting methylation toward user-defined DNA sequences. Directing methylation toward single CpG sites within a genome would provide a means to examine the effects of single epigenetic alterations ... -
TARGETING CANCER MUTATIONS
(Johns Hopkins UniversityUSA, 2020-05-15)If the first revolution of cancer research established the cellular basis of cancer, the second revolution defined its genetic basis. The past decade has seen astounding advances in our understanding of cancer genetics and ... -
Targeting Canonical and Noncanonical Hedgehog Signaling Pathways in Cancer
(Johns Hopkins UniversityUSA, 2014-03-26)The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. In the studies described here I demonstrate how mebendazole (MBZ), a benzimidazole ... -
Targeting CAPN9/CAPNS2 Activity as a Therapeutic Strategy for the Treatment of Transforming Growth Factor Beta-Induced Mesenchymal Transition and Associated Pathologies
(Johns Hopkins UniversityUSA, 2015-03-25)High expression and/or activity of calpain proteases has been associated with the development of fibrosis, but a mechanistic explanation of their role in this process remains to be defined. In this work, we show that ... -
Targeting early stages in non-mammalian isoprenoid biosynthesis: 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and reductoisomerase (IspC).
(Johns Hopkins UniversityUSA, 2013-11-25)This dissertation research is focused on mechanistic studies of early stage, non-mammalian isoprenoid biosynthesis enzymes, toward the development of selective inhibitors that will target serious human pathogens including ... -
TARGETING FARNESYLATION AS A NOVEL THERAPEUTIC APPROACH IN HRAS-MUTANT RHABDOMYOSARCOMA
(Johns Hopkins UniversityUSA, 2022-03-30)Activating RAS mutations are found in a subset of fusion-negative rhabdomyosarcoma (FN-RMS), and therapeutic strategies to directly target RAS in these tumors have been investigated, without clinical success to date. A ...