Now showing items 1-7 of 7

    • Different States and Different Populations of Neural Stem Cells in the Adult Hippocampus 

      Stadel, Ryan P (Johns Hopkins UniversityUSA, 2015-03-13)
      Over the past couple of decades, a central dogma in neuroscience has been overturned, the belief that no new neurons are generated in the adult mammalian brain. It has now been shown that within discrete regions there is ...
    • Direction Sensing During Collective Cell Migration 

      Cai, Danfeng (Johns Hopkins UniversityUSA, 2014-10-06)
      Collective cell migration is an important process not only in development but also in diseases. The Drosophila ovary, with its relatively simply structure, genetic tractability, and the compatibility with live imaging, is ...
    • GPR124 IS A NOVEL CO-ACTIVATOR OF CANONICAL WNT SIGNALING 

      Zhou, Yulian (Johns Hopkins UniversityUSA, 2015-05-26)
      Canonical Wnt signaling in endothelial cells (ECs) is required for vascularization of the central nervous system (CNS) and for formation and maintenance of barrier properties unique to CNS vasculature. Gpr124 is an orphan ...
    • Identification of telomere length regulators by pooled library screening 

      Wang, Steven (Johns Hopkins UniversityUSA, 2017-01-19)
      Telomeres protect chromosome ends from damage (d'Adda di Fagagna et al., 2003). In the presence of telomerase, telomere length is maintained at an established equilibrium (Greider, 1996). Alterations to this equilibrium ...
    • MECHANISITIC STUDIES OF CHEMICAL BIOLOGY PROBES REGULATING MTOR PATHWAY 

      Li, Ruojing; 0000-0001-7559-3929 (Johns Hopkins UniversityUSA, 2016-12-29)
      Mechanistic target of rapamycin (mTOR) plays an essential role in sensing a myriad of environmental cues including nutrients and growth factor stimulation to regulate cell growth and proliferation. mTOR independently ...
    • Mechanisms of Yki-mediated transcriptional regulation of the Hippo signaling pathway 

      Qing, Yun (Johns Hopkins UniversityUSA, 2016-08-25)
      The Hippo signaling pathway is a conserved pathway in regulating organ size. Deregulation of the pathway also exerts crucial effects on cancer development. In Drosophila, the Hippo pathway restricts tissue growth by ...
    • The Regulation and Function of miR-26 in Normal Physiology and Tumorigenesis 

      Zeitels, Lauren Rachel (Johns Hopkins UniversityUSA, 2015-03-13)
      It has become increasingly clear that the dysregulation of microRNAs (miRNAs), small (18-21nt) noncoding RNAs, plays an integral role in both normal physiology and disease. Downregulation of miR-26 family members has been ...