Browsing ETD -- Doctoral Dissertations by Issue Date
Now showing items 1-20 of 5022
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THE IMPACT OF CHILD SURVIVAL INTERVENTIONS IN INDONESIA
(jhuJohns Hopkins University, 1990)Health program evaluations typically are concerned with either mortality or nutritional status as an outcome variable. Health interventions can affect both child survival and nutritional status, therefore an impact ... -
DEVELOPMENT OF LIDAR TECHNIQUES TO ESTIMATE ATMOSPHERIC OPTICAL PROPERTIES
(Johns Hopkins University, 2006-08-03)The modified methodologies for one-directional and multiangle measurements, which were used to invert the data of the JHU elastic lidar obtained in clear and polluted atmospheres, are presented. The vertical profiles ... -
Macromolecular Studies of the Dynamic Structure and Mechanical Properties of the Endothelial Surface Layer
(Johns Hopkins University, 2006-08-03)The endothelial surface layer (ESL) is a micron-scale macromolecular lining of the luminal side of blood vessels, composed of proteoglycans, glycoproteins, polysaccharides and plasma proteins in dynamic equilibrium. Its ... -
ORGANIZING FORCES AND CONFORMATIONAL ACCESSIBILITY IN THE UNFOLDED STATE OF PROTEINS
(Johns Hopkins University, 2006-08-03)For over fifty years, the unfolded state of proteins had been thought to be featureless and random. Experiments by Tanford and Flory confirmed that unfolded proteins possessed the same dimensions as those predicted of a ... -
CONVERSING IN COLONY: THE BRASÍLICA AND THE VULGAR IN PORTUGUESE AMERICA, 1500-1759
(Johns Hopkins University, 2006-08-03)This dissertation casts light on a topic hitherto unstudied, of the colony-wide lingua francas of Portuguese America, the Brasílica and the Vulgar. It examines the first two hundred and fifty years of colonial history in ... -
A Cosmopolitan Community: Hanseatic Merchants in the German-American Atlantic of the Nineteenth Century
(Johns Hopkins University, 2006-08-03)This thesis examines the experience of a group of long-distance, wholesale merchants from the Hanseatic city-republic of Bremen who dominated American-German trade during the nineteenth century. It places their history in ... -
SOLUTION TO MEMBRANE CONFORMATIONAL CHANGE OF BCL-XLΔTM
(Johns Hopkins University, 2006-08-03)The central question that this thesis project addresses is the pH-dependent solution-to-membrane conformational change of Bcl-XLΔTM in vitro. Evidence exists for both solution and membrane-inserted conformations playing ... -
ELECTRON TRANSFER AND COORDINATION REACTIONS BETWEEN MnIII,IVO2(BIRNESSITE), MnIIIOOH(MANGANITE), AND OXYGEN-DONOR ALIPHATIC COMPOUNDS
(Johns Hopkins University, 2006-08-03)Organic compounds possess adsorptive, complexant, and reductant properties that determine pathways and rates of reactions with Mn (hydr)oxides. Mn (hydr)oxides are among the most reactive oxidants found in soils and ... -
Twin Crisis and Fixed-Exchange-Rate Regimes: Theory and Related Empirical Studies
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Essays on Fiscal Transparency and In°ation Expectations
(Johns Hopkins University, 2006-08-03)This dissertation comprises two related essays on ¯scal transparency and a third essay on in°ation expectations. The ¯rst chapter provides a brief introduction to the next three chapters. The second chapter proposes ... -
RANDOM DRIFT: CHANCE AND EXPLANATION IN EVOLUTIONARY BIOLOGY
(Johns Hopkins University, 2006-08-03)The central claim for which I argue in this dissertation is that there are important phenomena that occur by random drift that evolutionary biologists explain using a strategy I term “process explanation.” This claim ... -
EXPERIENCES OF TOLERANCE: IMMANENCE, TRANSCENDENCE, HILARITAS
(Johns Hopkins University, 2006-08-03)The objective of this study is to think the intersection of tolerance and toleration. By tolerance I mean the disposition of embodied agents to endure circuits of pain and suffering. By toleration I mean the institutional ... -
COMPUTATIONAL AND EXPERIMENTAL STUDIES OF INTRINSICALLY DISORDERED PROTEINS
(Johns Hopkins University, 2006-08-03)There is growing interest in proteins that lack a stable and well-defined three-dimensional structure, often referred to as intrinsically disordered proteins, but have functionally important properties that depend on the ... -
GENE EXPRESSION PROFILING IN ISCHEMIC AND NONISCHEMIC CARDIOMYOPATHY
(Johns Hopkins University, 2006-08-03)Background Despite our growing understanding of the pathophysiology and management of heart failure, there exist no strategies to individualize therapy using predictors of long-term prognosis and response to therapy. ... -
The molecular mechanics of start site selection during eukaryotic translation initiation
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GLUTAMATE TRANSPORTER FUNCTION AT EXCITATORY SYNAPSES
(Johns Hopkins University, 2006-08-03)Glutamate uptake by high-affinity plasma membrane transporters is essential for maintaining a low ambient level of glutamate and avoiding neurotoxicity. At excitatory synapses, glutamate transporters help to terminate ... -
MATERNAL MORBIDITY IN RURAL BANGLADESH: WOMEN’S PERCEPTIONS AND CARE SEEKING BEHAVIORS
(Johns Hopkins University, 2006-08-03)Background Death and illness related to pregnancy and childbirth are significant health problems in developing countries. The World Health Organization estimates that 529,000 women die from complications related to ... -
The role of histone modifications in the reversal of abnormal gene silencing in cancer
(Johns Hopkins University, 2006-08-03)Two of the main mechanisms by which epigenetic changes can occur are DNA methylation and chromatin conformation changes. Aberrant hypermethylation of promoter CpG islands is associated with silencing of key genes in cancer. ... -
BEHIND THE IRON CURTAIN: DEXRAS1 MEDIATES GLUTAMATEN-MDA INDUCED NEURONAL IRON UPTAKE
(Johns Hopkins University, 2006-08-03)Iron is an enigmatic molecule – a divalent metal absolutely required for life, but toxic in excess. Because of this dual nature, iron trafficking within the cell is tightly regulated, with little free iron available in ... -
MEMBRANE PROTEIN FOLDING: THE ROLE OF AMINO ACID SEQUENCE IN SPECIFYING THE STABILITY AND CONFORMATION OF TRANSMEMBRANE OLIGOMERS
(Johns Hopkins University, 2006-08-03)Proteins carry out essential processes of the cell, and to function properly they must adopt and maintain their native fold. Both thermodynamic and structural data for soluble protein have provided insight into the forces ...