Browsing ETD -- Doctoral Dissertations by Subject "CAL"
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The CFTR-Associated Ligand (CAL) Arrests the Trafficking of the Mutant deltaF508 CFTR Channel in the ER Contributing to Cystic Fibrosis (Johns Hopkins UniversityUSA, 2015-09-28)Statement of Problem: ΔF508-CFTR is the most prevalent mutation among patients with Cystic Fibrosis. At present, there are no successful FDA-approved therapies for treatment. The CFTR-Associated Ligand (CAL) is a PDZ domain ...