Now showing items 1-2 of 2

    • Mechanistic Insights into the Auto-Regulation of PTEN and Its Related HECT E3 Ligases 

      Chen, Zan; 0000-0001-9925-872X (Johns Hopkins UniversityUSA, 2017-08-14)
      PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase that dephosphorylates PIP3 to PIP2, and negatively regulates the PI3K/AKT signaling pathway. PTEN is an essential tumor suppressor gene ...
    • PINK1: from enzymatic function to modeling Parkinson’s disease 

      Scarffe, Leslie A; 0000-0003-0673-3937 (Johns Hopkins UniversityUSA, 2016-12-15)
      The loss of PTEN-Induced Kinase 1 (PINK1) is the second most common cause of autosomal recessive Parkinson’s disease. PINK1 has been shown to play an important role in mitochondrial quality control by regulating the function ...