The sequencing of the human genome ushered in the era of high-throughput biology. Rapid, whole cell analysis is replacing the molecular reductionist approach of the last century. Microarrays are one of the main high-throughput ...

This thesis is compiled from the various projects I completed as a graduate student at the Johns Hopkins University Physics Department. The first project studied threshold effects in excited charmed baryon decays. The ...

The yeast knockout collections provide opportunities to perform massively parallel phenotyping of deletion mutants for almost every yeast open reading frame. I used the knockout collection to screen for synthetic lethal ...

For over fifty years, the unfolded state of proteins had been thought to be featureless and random. Experiments by Tanford and Flory confirmed that unfolded proteins possessed the same dimensions as those predicted of a ...

Organohalide compounds are one of major pollutants on Environmental Protection Agency’s (EPA) contaminants candidate list (www.epa.gov.safewater). Chapter 1 represents the overview of environmental detoxification of ...

This thesis is about estimating probabilistic models to uncover useful hidden structure in data; specifically, we address the problem of discovering syntactic structure in natural language text. We present three new ...

This dissertation examines the various pathways to transnationality taken by civil society organizations challenging the negotiations of free trade agreements in the Americas. It proposes a relational approach that focuses ...

OBJECTIVE: To examine the association between antidepressant use and the likelihood of being employed among HIV-positive persons receiving highly active antiretroviral therapy (HAART). DATA SOURCES: Panel (longitudinal), ...

The central claim for which I argue in this dissertation is that there are important phenomena that occur by random drift that evolutionary biologists explain using a strategy I term “process explanation.” This claim ...