Organohalide compounds are one of major pollutants on Environmental Protection Agency’s (EPA) contaminants candidate list (www.epa.gov.safewater). Chapter 1 represents the overview of environmental detoxification of ...

The sequencing of the human genome ushered in the era of high-throughput biology. Rapid, whole cell analysis is replacing the molecular reductionist approach of the last century. Microarrays are one of the main high-throughput ...

This thesis is compiled from the various projects I completed as a graduate student at the Johns Hopkins University Physics Department. The first project studied threshold effects in excited charmed baryon decays. The ...

For over fifty years, the unfolded state of proteins had been thought to be featureless and random. Experiments by Tanford and Flory confirmed that unfolded proteins possessed the same dimensions as those predicted of a ...

The yeast knockout collections provide opportunities to perform massively parallel phenotyping of deletion mutants for almost every yeast open reading frame. I used the knockout collection to screen for synthetic lethal ...

Cochlear implants have helped many profoundly deaf individuals regain auditory communication. However, the extent to which hearing is restored is variable, and may depend on fundamental changes to the auditory pathways ...

There is growing interest in proteins that lack a stable and well-defined three-dimensional structure, often referred to as intrinsically disordered proteins, but have functionally important properties that depend on the ...

When separately written programs are composed so that they may cooperate, they may instead destructively interfere in unanticipated ways. These hazards limit the scale and functionality of the software systems we can ...

The objective of this study is to think the intersection of tolerance and toleration. By tolerance I mean the disposition of embodied agents to endure circuits of pain and suffering. By toleration I mean the institutional ...