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Occupational Allergy and Asthma Among Laboratory Animal Workers: The Role of Respiratory Protection
(Johns Hopkins University, 2014-11-07)
ABSTRACT
Problem: Workers exposed to laboratory animal allergens develop laboratory animal allergies (LAA) (sensitization accompanied by allergic symptoms) which often progresses to occupational asthma (OA). Although ...
Forelimb myology and the evolutionary relationships of the aardvark, Orycteropus afer, and other small afrotheres
(Johns Hopkins University, 2014-06-20)
The aardvark, Orycteropus afer, is the sole surviving member of the order Tubulidentata, and it has such unusual morphology that few skeletal or dental characters link it to other living mammals. Instead researchers compare ...
The Topology, Regulation, and Function of Cardiolipin Remodeling in Saccharomyces cerevisiae
(Johns Hopkins University, 2014-04-29)
Cardiolipin (CL) is a unique phospholipid that resides exclusively within mitochondria, and is required for the optimal function of numerous mitochondrial processes. After synthesis, CL undergoes an evolutionarily conserved ...
Identification and Characterization of a Stem Cell-Like Population in Ovarian Cancer
(Johns Hopkins University, 2014-01-31)
Eighty percent of patients with advanced ovarian cancer show an initial clinical response to therapy, but seventy-five percent of these patients eventually relapse. This transient clinical response would be consistent ...
The Novelistic Poem and the Poetical Novel: Towards a Theory of Generic Interrelation in the Romantic Period
(Johns Hopkins University, 2014-08-13)
This dissertation examines the shifting set of formal and conceptual relations that have structured the intertwined development and reception of “the novel” and “poetry” since the Romantic period. In Part One, I focus on ...
The Economics of Pharmaceutical Development: Costs, Risks, and Incentives
(Johns Hopkins University, 2013-09-26)
This dissertation addresses three open questions related to the economics of pharmaceutical development. First, how much does it cost to conduct a clinical trial? Second, what effect has the model policy for incentivizing ...
A STUDY OF THE MECHANISM BEHIND THE HLA-DO ACCESORY MOLECULE AND ITS GREATER ROLE IN CLASS II ANTIGEN PRESENTATION
(Johns Hopkins University, 2014-06-02)
Antigen presentation is the first step in generating an adaptive immune response to a foreign pathogen. The antigen processing system digests antigens into small peptide fragments, which are bound to major histocompatibility ...
Developing Membrane Active Peptides for Endosomal Escape of Macromolecules
(Johns Hopkins University, 2015-03-16)
Membrane Active Peptides (MAPs) are an important class of short protein sequences that hold the potential to be used for a number of varied purposes such as antibacterial, antiviral, and drug delivery based therapies. ...
Advances in Shake Table Control and Substructure Shake Table Testing
(Johns Hopkins University, 2014-06-18)
Shake table tests provide a true representation of seismic phenomena including a fully dynamic environment with base excitation of the test structure. For this reason shake tables have become a staple in many earthquake ...
New insights into the regulation of D-serine and glycine in the central nervous system
(Johns Hopkins University, 2014-03-21)
D-serine is an endogenous ligand for NMDARs generated from L-serine by the enzyme serine racemase (Srr). Both neuronal and glial localizations have been reported for D-serine and Srr. 3-phosphoglycerate dehydrogenase ...