Now showing items 1-8 of 8
Advancing Magnetic Resonance Spectroscopy and Endoscopy with Prior Knowledge
(Johns Hopkins University, 2014-06-09)
Reconstruction is key to the generation of anatomic, functional and biochemical information in the field of Magnetic Resonance (MR) in medicine. Here, prior knowledge based on various conditions is utilized through ...
Statistical methods for epigenetic data and structural magnetic resonance imaging
(Johns Hopkins University, 2016-04-04)
This dissertation introduces novel statistical methods for the analysis of high-dimensional biomedical data. First, we present a normalization method for DNA methylation microarray data, called Functional normalization ...
NOVEL MRI APPROACHES FOR QUANTITATIVE ASSESSMENT OF CORONARY ARTERIES AND VENTRICULAR FUNCTION
Despite advances in screening techniques and prevention guidelines, cardiovascular disease remains the leading non-communicable disease with 17 million deaths worldwide in 2008. Approximately 6% of American adults had a ...
Steady-state Susceptibility Contrast MRI of Breast Cancer Angiogenesis: Preclinical Validation and Application
Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...
DEVELOPMENT AND APPLICATION OF NOVEL PHYSIOLOGICAL MRI METHODS TO IMAGE CHANGES IN OXYGENATION
This dissertation details the application of novel MRI methods (VASO and APT MRI) to acute stroke as well as the work to develop a novel MRI technique to image oxygenation in the brain.
IN VIVO DIFFUSION WEIGHTED MAGNETIC RESONANCE SPECTROSCOPY IN MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is a complex CNS disease in which inflammation, demyelination and neuroaxonal degeneration are concurrent processes. MS therapies developed to date are directed at the immune-mediated, inflammatory ...
Novel Techniques in Projection-based Motion Tracking in Cardiac Magnetic Resonance Imaging
(Johns Hopkins University, 2017-01-23)
Magnetic resonance imaging (MRI) is indispensable to the medical imaging of the heart because of its ability to manipulate soft tissue contrast, to image both 2D and 3D regions in arbitrary orientations, and its lack of ...
Deformable Image Registration for Surgical Guidance using Intraoperative Cone-Beam CT
(Johns Hopkins University, 2017-01-03)
Accurate localization of the surgical target and adjacent normal anatomy is essential to safe and effective surgery. Preoperative computed tomography (CT) and/or magnetic resonance (MR) images offer exquisite visualization ...