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THE EFFECT OF ADIPOSITY ON DISEASE OUTCOMES IN WOMEN WITH BREAST CANCER
(Johns Hopkins University, 2015-11-04)
There is accumulating evidence that obesity has a significant role in breast cancer (BC) prognosis. Among women with BC, obesity at diagnosis and weight gain after diagnosis may increase risk for BC recurrence and death, ...
CALCIUM AT THE PUMP: REGULATION OF INTRACELLULAR CALCIUM BY SECRETORY PATHWAY CALCIUM ATPASE ISOFORM 2 (SPCA2) IN MODELS OF LACTATION AND BREAST CANCER
(Johns Hopkins University, 2013-09-06)
Secretory Pathways Calcium ATPase 2 (SPCA2) is a non-redundant isoform of SPCA
expressed in highly secretory cells. In this study we aimed to investigate physiological
regulation of SPCA2 as a possible regulator of calcium ...
Global Analysis of the PI3K Signaling Pathway
(Johns Hopkins University, 2015-12-28)
The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell ...
THE HOMEOBOX PROTEIN HOXC10 IS OVEREXPRESSED IN BREAST CANCER AND INCREASES RESISTANCE TO CHEMOTHERAPY
(Johns Hopkins University, 2013-10-16)
Background. Drug resistance is a major limiting factor in the success of targeted cancer therapies resulting in failure of treatment. A molecular understanding of the underlying mechanisms is essential to predict, prevent ...
Synthesizing Data Sources to Develop and Update Risk Models
(Johns Hopkins University, 2014-06-19)
Building risk models from multiple different sources of data allows researchers to incorporate the best available information on key model parameters. In this thesis, we develop and apply methodology for optimally combining ...
COMBINATION IMMUNOTHERAPY TARGETING IMMUNOSUPPRESSIVE SIGNALS IN THE TUMOR MICROENVIRONMENT PREVENTS CANCER PROGRESSION IN BREAST AND PANCREATIC CANCER
(Johns Hopkins University, 2015-02-17)
Mechanisms of immune tolerance and suppression occur early at the site of developing tumors and inhibit protective responses induced by cancer vaccines, limiting their efficacy in the treatment of cancer. Combinatorial ...
Steady-state Susceptibility Contrast MRI of Breast Cancer Angiogenesis: Preclinical Validation and Application
(Johns Hopkins University, 2014-02-07)
Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...
CCL9 INDUCED BY TGF-β SIGNALING IN MYELOID CELLS ENHANCES TUMOR CELL SURVIVAL IN THE PREMETASTATIC LUNG
(Johns Hopkins University, 2015-04-09)
The majority of cancer patients die from metastasis. To achieve metastasis, tumor cells must first survive and then proliferate to form colonies. Compelling data have shown the indispensable participation of host ...
ENGINEERING THREE-DIMENSIONAL MODELS OF MICROTISSUE DEVELOPMENT
(Johns Hopkins University, 2015-11-18)
This research addresses the need for more accurate three-dimensional, biomimetic, in vitro models to replicate and study in vivo processes outside normal physiological contexts. Three models are explored in this work: ...
ONCOGENIC PROPERTIES AND TARGETING OF NTRK1 IN BREAST CANCER
(Johns Hopkins University, 2018-03-23)
Triple negative breast cancers (TNBC) comprise a highly aggressive cancer subtype with high mortality rates, high frequency of metastatic disease and a lack of targeted therapies. A fraction of these cancers also demonstrate ...