Secretory Pathways Calcium ATPase 2 (SPCA2) is a non-redundant isoform of SPCA expressed in highly secretory cells. In this study we aimed to investigate physiological regulation of SPCA2 as a possible regulator of calcium ...

The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell ...

There is accumulating evidence that obesity has a significant role in breast cancer (BC) prognosis. Among women with BC, obesity at diagnosis and weight gain after diagnosis may increase risk for BC recurrence and death, ...

Background. Drug resistance is a major limiting factor in the success of targeted cancer therapies resulting in failure of treatment. A molecular understanding of the underlying mechanisms is essential to predict, prevent ...

Mechanisms of immune tolerance and suppression occur early at the site of developing tumors and inhibit protective responses induced by cancer vaccines, limiting their efficacy in the treatment of cancer. Combinatorial ...

Angiogenesis is essential to the growth and spread of cancer, making it a promising therapeutic target. However, no anti-angiogenic drug is currently approved to treat breast cancer. Furthermore, there are no clinically ...

Building risk models from multiple different sources of data allows researchers to incorporate the best available information on key model parameters. In this thesis, we develop and apply methodology for optimally combining ...

This research addresses the need for more accurate three-dimensional, biomimetic, in vitro models to replicate and study in vivo processes outside normal physiological contexts. Three models are explored in this work: ...

The majority of cancer patients die from metastasis. To achieve metastasis, tumor cells must first survive and then proliferate to form colonies. Compelling data have shown the indispensable participation of host ...