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ONCOGENIC PROPERTIES AND TARGETING OF NTRK1 IN BREAST CANCER
(Johns Hopkins University, 2018-03-23)
Triple negative breast cancers (TNBC) comprise a highly aggressive cancer subtype with high mortality rates, high frequency of metastatic disease and a lack of targeted therapies. A fraction of these cancers also demonstrate ...
Sparsity and scarcity: Multiomic studies in a low resource setting (A study in archival FFPE cancer tissue)
(Johns Hopkins University, 2016-11-29)
Archival formalin-fixed, paraffin-embedded (FFPE) tissues are an invaluable resource for biomarker discovery due to their vast number in pathology laboratories and availability of high-quality, long-term clinical information. ...
Preventive screening utilization in nurses and in the general population: a Taiwan study
(Johns Hopkins University, 2015-09-01)
Purpose:
The growing incidence of cancer in middle-aged and elderly populations has increased the importance of preventive measures such as cancer screening programs. In 1996, the National Health Insurance Bureau in ...
The Role of the Secretory Pathway Ca2+-ATPase, SPCA2 in Breast Cancer Evolution
(Johns Hopkins University, 2018-03-27)
Calcium dysregulation in breast cancer can occur early during dysplasia in mammary tissue, and persist throughout the progression of cancer. This perturbation to the homeostasis of calcium can be detrimental to the normal ...
ADVANCEMENTS IN GLYCOMETABOLIC ENGINEERING AND CARBOHYDRATE DRUG DESIGN
(Johns Hopkins University, 2018-04-16)
A near universal feature of virtually every major disease in humans has been the observation that proteins and lipids have perturbed patterns of glycosylation when compared to healthy tissues and cells, indicating that a ...
Epigenetic reprogramming of myeloid-derived suppressor cells sensitizes breast and pancreatic cancers to immune checkpoint inhibition
(Johns Hopkins University, 2019-03-27)
Immune checkpoint inhibition (ICI) has revolutionized treatment in cancers that are naturally immunogenic by enabling infiltration of T cells into the tumor microenvironment (TME) and promoting cytotoxic signaling pathways. ...
The Role of Mutant PIK3CA and TP53 in Human Breast Carcinogenesis
(Johns Hopkins University, 2015-03-19)
Breast cancer is the second leading cause of cancer-associated deaths among women in the United States, with greater than 40,000 women dying each year from this disease. While specific DNA mutations have been shown to be ...
CALCIUM AT THE PUMP: REGULATION OF INTRACELLULAR CALCIUM BY SECRETORY PATHWAY CALCIUM ATPASE ISOFORM 2 (SPCA2) IN MODELS OF LACTATION AND BREAST CANCER
(Johns Hopkins University, 2013-09-06)
Secretory Pathways Calcium ATPase 2 (SPCA2) is a non-redundant isoform of SPCA
expressed in highly secretory cells. In this study we aimed to investigate physiological
regulation of SPCA2 as a possible regulator of calcium ...
Global Analysis of the PI3K Signaling Pathway
(Johns Hopkins University, 2015-12-28)
The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell ...
THE EFFECT OF ADIPOSITY ON DISEASE OUTCOMES IN WOMEN WITH BREAST CANCER
(Johns Hopkins University, 2015-11-04)
There is accumulating evidence that obesity has a significant role in breast cancer (BC) prognosis. Among women with BC, obesity at diagnosis and weight gain after diagnosis may increase risk for BC recurrence and death, ...