Now showing items 1-10 of 10
HYPOXIA-INDUCIBLE FACTORS ENHANCE GLUTAMATE SIGNALING IN CANCER CELLS
(Johns Hopkins University, 2014-06-18)
Hypoxia-inducible factors (HIFs) are transcription factors that are essential in many developmental, physiological and pathophysiological processes. HIFs can be induced in response to reduced oxygen availability (hypoxia) ...
Early-Life Exposures and Adult Cancer Risk: A Life Course Approach to Cancer Prevention
(Johns Hopkins University, 2015-12-21)
Background Despite emerging evidence indicating the potential importance of early-life exposures for adult cancer risk, there is limited research investigating cancer risk factors in early-life. The goals of this ...
Risk factors for oral HPV persistence and HPV-associated cancer
(Johns Hopkins University, 2016-03-14)
Background: Persistent human papillomavirus (HPV) infection is a well-known cause of cervical and anogenital cancers. In the past decade, oral HPV infection was established as a cause of oropharyngeal squamous cell carcinoma ...
Engineering Of Polymer/DNA Nanoparticles To Improve Gene Delivery Efficiency In Vivo
(Johns Hopkins University, 2015-08-21)
Nanoparticle-mediated non-viral gene delivery offers an exciting alternative to conventional viral vectors. However, a main roadblock to their future clinical application lies in the poor therapeutic delivery efficiency ...
SAICAR acts as a master metabolite in cancer cell growth, survival, and proliferation
(Johns Hopkins University, 2014-09-15)
Cancer cells must reprogram their metabolic networks to adapt to stress conditions, which are commonly found in a tumor microenvironment. To accomplish this, cancer cells alter expression and regulation of many target ...
Low-grade inflammation, immune capacity, and cancer
Inflammation is a well-established etiological factor in carcinogenesis. The immune system may also have the capacity to identify and clear malignant cells in a process known as tumor immunosurveillance. The objective of ...
CREDENTIALING THE DNA METHYLATION MAINTENANCE PROTEIN UHRF1 AS A TARGET FOR ANTICANCER THERAPY
Cancer is a disease of genome alterations that drive uncontrolled growth. The most challenging aspect of cancer treatment is that there are many avenues to enable proliferation within the cell, including alterations to ...
Evaluating Geographic Cancer Disparities in Baltimore City, Maryland
(Johns Hopkins University, 2016-04-04)
Research and policy continue to hold cancer as a top priority in the United States due to its public health burden. As the aging population increases, it is an issue that will likely continue to grow in scope. However, ...
Cancer-Associated Isocitrate Dehydrogenase Mutation: Structural Basis of Enzyme Inactivation
(Johns Hopkins University, 2014-01-09)
Isocitrate dehydrogenase enzymes catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate. Somatic point mutations in the IDH1 gene are observed in glioblastoma multiforme and acute myeloid leukemia, with a ...
An Exploration of the Role of Family Members in Pre-Surgical Visits
(Johns Hopkins University, 2017-07-11)
There were 46 visits (75%) in which companions were present, and 15 (25%) in which companions were not present.