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DECIPHERING THE ROLE OF DNMT3B IN REGULATING DNA METHYLATION AND EPIGENETIC MODULATION OF TRANSCRIPTIONAL SILENCING
(Johns Hopkins University, 2014-07-02)
DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. DNA methylation patterns are not randomly distributed, instead they are compartmentalized by region. In normal cells ...
EFFECTOR BOTTLENECK: MICROBIAL REPROGRAMMING OF HUMAN NEUTROPHIL TRANSCRIPTION BY ANAPLASMA PHAGOCYTOPHILUM
(Johns Hopkins University, 2015-03-09)
Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium that infects human neutrophils. Once infected, the neutrophil shows marked functional aberrations, ...
Kabuki syndrome: Reversing Intellectual Disability by Promoting Open Chromatin
(Johns Hopkins University, 2015-11-16)
Kabuki syndrome (KS) is a rare intellectual disability syndrome caused by mutations in two genes (KMT2D and KDM6A) both involved in promoting open chromatin. If an imbalance between open and closed chromatin states is ...
CREDENTIALING THE DNA METHYLATION MAINTENANCE PROTEIN UHRF1 AS A TARGET FOR ANTICANCER THERAPY
Cancer is a disease of genome alterations that drive uncontrolled growth. The most challenging aspect of cancer treatment is that there are many avenues to enable proliferation within the cell, including alterations to ...
IN UTERO EXPOSURE TO MATERNAL IMMUNE ACTIVATION AND AUTISM SPECTRUM DISORDER
(Johns Hopkins University, 2017-04-28)
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication, and repetitive behavior and stereotypical interests. First we describe what is known about ...
STRATEGIES TO MODEL AND CIRCUMVENT ACQUIRED RESISTANCE TO THERAPEUTICS IN SMALL CELL LUNG CANCER
(Johns Hopkins University, 2016-10-28)
Small cell lung cancer (SCLC) is an extremely aggressive, pulmonary malignancy linked to lifetime smoking of cigarette tobacco. Most SCLC is diagnosed in the metastatic setting and surgical resection is rarely performed. ...