ETD--Doctoral Dissertations: Recent submissions
Now showing items 1-20 of 1766
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AN ANALYSIS of PERSON-RELATED, ENVIRONMENT-RELATED, and SCHOOL CONTEXTUAL FACTORS ASSOCIATED with a BEHAVIOR-RELATED FACTOR of TEACHER VICTIMIZATION by STUDENTS
(Johns Hopkins UniversityUSA, 2014-05-14)The problem of teacher victimization by students (TVS) was investigated in this study. The theoretical approach employed was rooted in Bandura’s Social Cognitive Theory (SCT) which involves Triadic Reciprocal Determinism ... -
Pathogenesis of Myocarditis and Inflammatory Dilated Cardiomyopathy: the Sign of Four
(Johns Hopkins UniversityUSA, 2014-04-10)Myocarditis and inflammatory dilated cardiomyopathy (DCMi) are major causes of heart failure in individuals below the age of 40. In the work presented in this dissertation, using a model of mouse experimental autoimmune ... -
Applying Complexity Theory to Chinese Overseas Investment in Oil: Continuous Adaptation
(Johns Hopkins UniversityUSA, 2014-04-01)This dissertation applied complexity theory as a conceptual framework for understanding Chinese National Oil Companies’ (NOCs) continuously changing investment strategies. Complexity theory offers an alternative way of ... -
ANTICOAGULATION AND NEUROMONITORING DURING EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO)
(Johns Hopkins UniversityUSA, 2014-03-31)Extracorporeal membrane oxygenation (ECMO) is a life-saving technique of cardiopulmonary bypass employed in intensive care units since 1976.1 ECMO is used in >1,000 children each year for cardiopulmonary failure refractory ... -
Genetic and Environmental Determinants of Food Allergy
(Johns Hopkins UniversityUSA, 2014-04-03)Introduction: This thesis attempts to answer several questions about the epidemiology of pediatric allergy, including (1) the prevalence of pediatric food allergy in the United States and its changes over time, (2) whether ... -
CYTOCHROME P450 3A-MEDIATED PHARMACOKINETIC VARIATIONS FOR ANTI-INFECTIVE AGENTS
(Johns Hopkins UniversityUSA, 2014-03-28)Two highly homologous enzymes, cytochrome P450 enzyme 3A4 (CYP3A4) and CYP3A5 play predominant roles in drug elimination by metabolizing more than half of the marketed drugs. This thesis focuses on pharmacokinetics of ... -
Symptom-free in zero-g? Novel techniques for rapid assessment of vestibulo-ocular function and their use in predicting performance from baseline metrics
(Johns Hopkins UniversityUSA, 2014-03-27)Spaceflight elicits adaptive changes in neurovestibular signaling to accommodate exposure to novel gravity levels. With the prospect of longer-duration missions to Mars and beyond, NASA is currently faced with two immediate ... -
Regulated microRNA biogenesis generates specificity in pro-growth neuronal gene expression
(Johns Hopkins UniversityUSA, 2014-03-27)Control of translation is a fundamental source of regulating gene expression. Brain-derived neurotrophic factor (BDNF) is a critical activity-dependent modulator of gene expression, which can regulate both transcription ... -
Targeting Canonical and Noncanonical Hedgehog Signaling Pathways in Cancer
(Johns Hopkins UniversityUSA, 2014-03-26)The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. In the studies described here I demonstrate how mebendazole (MBZ), a benzimidazole ... -
STEM CELLS ARE HIGHLY ENRICHED SOURCES OF AUTOANTIGENS TARGETED IN SCLERODERMA – IMPLICATIONS FOR PATHOGENESIS
(Johns Hopkins UniversityUSA, 2014-03-25)Myositis, scleroderma, and other systemic autoimmune diseases are united by many features, including (i) the presence of a self amplifying cycle of tissue destruction and immune system activation with a failure of homeostatic ... -
The role of policy in promoting women's health during pregnancy and postpartum
(Johns Hopkins UniversityUSA, 2014-03-26)This dissertation research, presented in three manuscripts, uses a variety of quantitative methods to inform the role that policy can play to promote healthy behaviors to improve women’s health during and after pregnancy. The ... -
Observing from the Margins: James Parkinson and the Shaking Palsy
(Johns Hopkins UniversityUSA, 2014-03-21)Abstract In 1817, James Parkinson (1755-1824) published An Essay on the Shaking Palsy, describing paralysis agitans, or the shaking palsy, a condition he believed to be a specific and newly characterized disease. The disease ... -
Molecular Design and Process Aspects of Pyromellitic and Oligosilane Small Molecule Organic Semiconductors
(Johns Hopkins UniversityUSA, 2014-03-21)Organic semiconductors comprise organic molecular or polymeric compounds that contain conjugated electron systems with delocalized molecular orbitals, in which holes and electrons can be transferred between adjacent molecular ... -
MODELING AND THERAPEUTIC TARGETING OF ENDOGENOUS IDH1-MUTANT GLIOMA
(Johns Hopkins UniversityUSA, 2014-03-21)Somatic mutations in Isocitrate Dehydrogenase 1 (IDH1) are frequent in low grade and progressive gliomas. IDH1 mutant tumors are phenotypically characterized by the increased production of 2-hydroxyglutarate (2-HG) from ... -
Endoscopic imaging and image-guided sampling for pancreatic neoplasia
(Johns Hopkins UniversityUSA, 2014-03-26)Background: Endoscopic ultrasound (EUS) provides high-resolution images of the pancreas. There are two fundamental echoendoscope designs, yet no data support use of one type over the other. Once lesion is detected, ... -
CHILDREN OF MEXICAN IMMIGRANTS’ COGNITIVE AND NONCOGNITIVE DEVELOPMENT IN TRADITIONAL AND NON-TRADITIONAL U.S. DESTINATIONS
(Johns Hopkins UniversityUSA, 2014-03-19)Over the last twenty-five years Mexican communities have spread throughout the United States beyond the traditional southwest (‘traditional destinations’) to ‘non-traditional’ destinations west and east of the Mississippi. ... -
Image Guided Robots for Urology
(Johns Hopkins UniversityUSA, 2014-03-20)This dissertation addresses the development of medical image-guided robots and their applications in urology. Image-guided robots integrate medical image information with robotic precision to assist the planning and execution ... -
MOLECULAR MECHANISMS OF MUTANT CARD11 SIGNALING TO NF-κB IN HUMAN DIFFUSE LARGE B CELL LYMPHOMA
(Johns Hopkins UniversityUSA, 2014-03-19)Upon antigen receptor stimulation in both B and T lymphocytes, the signaling adapter CARD11 transforms from a closed inactive state to an open active scaffold that assembles into a multiprotein complex, leading to the ... -
A NOVEL ROLE FOR SMAD6 IN THE BIOLOGY OF PANCREATIC CANCER
(Johns Hopkins UniversityUSA, 2014-03-20)Pancreatic cancer is a nearly uniformly lethal disease, with the five-year survival rate remaining a dismal five percent. Recently, our laboratory has associated the loss of SMAD4, a critical mediator of TGF-β and BMP ... -
Playing Guns: Avant-Garde Aesthetics and Revolutionary Violence
(Johns Hopkins UniversityUSA, 2014-03-18)Playing Guns theorizes the avant-gardes in relation to the following revolutionary movements from the extended Caribbean: the Mexican Revolution (Stridentism and Antonio Helú), the Cuban Revolution (Julio Cortázar), the ...