ETD -- Graduate theses
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For information about submitting electronic theses and dissertations, please see the ETD information page
Recent Submissions
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Intracellular delivery of dendrimer-based nanoconjugates for cancer and neuroinflammation
(Johns Hopkins UniversityUSA, 2016-05-25)Activated microglia/macrophages have been implicated as key players in many central nervous system (CNS) diseases, such as brain tumor and Rett syndrome, in which they secrete regulatory/inflammatory cytokines that either ... -
POLYMER-PEPTIDE SYSTEMS FOR THE OCULAR SURFACE AND MEDICAL DEVICES
(Johns Hopkins UniversityUSA, 2016-05-06)Hyaluronic acid (HA) wetting solutions effectively lubricate the ocular surface and are used clinically for corneal epithelial wound healing and to treat dry eye disorders resulting from Sjögren syndrome and keratoconjunctivitis ... -
Self-folding Microgrippers and Their Applications as BioMEM Systems
(Johns Hopkins UniversityUSA, 2016-05-03)Self-actuating microtools have evolved to be more efficient as diagnostic biological microelectromechanical (bioMEM) systems because of their miniature and robust designs. One of these microtool designs, namely microgrippers, ... -
Investigating Therapeutic Strategies for Treatment of Osteoarthritis in the Knee Joint
(Johns Hopkins UniversityUSA, 2016-05-03)Osteoarthritis (OA) is one of the most common chronic musculoskeletal diseases of the joints and is characterized by degradation of the articular cartilage as well as hypertrophy of the bone. This leads the clinical symptoms ... -
MATHEMATICAL CHARACTERIZATION OF INTERFACE INTERACTION NETWORKS
(Johns Hopkins UniversityUSA, 2016-05-02)Biological systems carry out complex functions such as DNA transcription, cell division, and signaling within and between cells through the collective effort of a diverse range of proteins. In these functional pathways, ... -
The Subcellular Localization of the Uncharacterized Human Disease-Associated Protein Potassium Channel Tetramerization Domain 13 (KCTD13)
(Johns Hopkins UniversityUSA, 2016-04-22)Human KCTD (potassium (K+) channel tetramerization domain (KCTD) proteins make up a family of 26 largely uncharacterized human proteins containing a single N-terminal BTB/POZ domain most closely related to the T1 domain ... -
KIDNEY FUNCTION, BONE-MINERAL METABOLISM MARKERS, AND FUTURE RISK OF PERIPHERAL ARTERY DISEASE: THE ATHEROSCLEROSIS RISK IN COMMUNITES (ARIC) STUDY
(Johns Hopkins UniversityUSA, 2016-04-22)Background: Kidney dysfunction is a known risk factor for lower-extremity peripheral artery disease (PAD). Although novel filtration markers like cystatin C and beta-2-microglobulin demonstrate stronger associations with ... -
Association of 1,5-anhydroglucitol, a biomarker of glucose peaks, with subclinical cardiovascular disease
(Johns Hopkins UniversityUSA, 2016-04-25)Background 1,5-anhydroglucitol (1,5-AG) is a biomarker of glucose peaks and has been associated with clinical cardiovascular disease. However, the association between 1,5-AG and subclinical cardiovascular disease is unknown. ... -
ACUTE STRESS-INDUCED CORTISOL ELEVATION ENHANCES MEMORY CONSOLIDATION OF SIMILAR ITEMS
(Johns Hopkins UniversityUSA, 2016-04-04)Though considerable evidence has indicated that stress-induced changes in cortisol crucially affect memory function, the precise relationship between cortisol and long-term memory remains poorly understood. Cortisol has ... -
Modeling Transportation Networks and Urban Traffic Dynamics: A Markovian Framework
(Johns Hopkins UniversityUSA, 2017-05-08)An urban transportation network is a complex and stochastic system with high degrees of unpredictability and uncertainty. While significant advances have been in modeling dynamic network traffic, existing efforts usually ... -
COMPREHENSIVE IN SILICO ASSESSMENT OF CANCER CELL LINE FIDELITY
(Johns Hopkins UniversityUSA, 2017-05-05)Since 1971, when US president Richard Nixon declared a “war against cancer”, an estimated $200 billion has been spend on research and drug development for cancer. Globally, the cancer incidence and the mortality rates have ... -
TOWARDS PAIN CONTROL BY MODELING THE INTERACTIONS IN A MAMMALIAN NERVE FIBER
(Johns Hopkins UniversityUSA, 2017-05-04)Objectives. Electrical stimulation of nerve fibers is used to treat various diseases. De- spite efforts to model the effects of stimulation, its underlying mechanisms remain unclear. This is because current mechanistic ... -
Label Free CEST MRI Detection of Hydrogen Peroxide and its Applications in Monitoring Oxygen Delivery for Tissue Engineering
(Johns Hopkins UniversityUSA, 2017-05-02)One of most formidable challenges in stem cell therapy is the initial hypoxia due to the lack of blood supply. Among the numerous oxygen-supplying systems that have been developed, hydrogen peroxide is suggested to be a ... -
UNMET HIV TREATMENT NEEDS TO PREVENT VERTICAL TRANSMISSION AMOMG FEMALE SEX WORKERS IN LESOTHO
(Johns Hopkins UniversityUSA, 2017-04-21)Background: Despite considerable advances made to increase the accessibility of non-barrier contraceptives across Sub-Saharan Africa, their use continues to be constrained within the region. Within the high HIV burden ... -
DESIGN AND CHARACTERIZATION OF SSDNA APTAMER CANDIDATES TO BIND BACTEROIDES FRAGILIS TOXIN SUBTYPES BFT-1 AND BFT-2
(Johns Hopkins UniversityUSA, 2017-04-21)Enterotoxigenic Bacteroides fragilis (ETBF) is a diarrheal pathogen that secretes a twenty kilo-dalton protein toxin, Bacteroides fragilis toxin (BFT) which binds to an uncharacterized receptor on the surface of epithelial ... -
Spanning Tree Representation of High Dimensional Data
(Johns Hopkins UniversityUSA, 2017-04-20)When analyzing a complex differentiation process with single-cell genomic data, ordering cells in a spanning tree with multiple branches is a useful way to study the dynamic activities of genes along the biological process. ... -
SINGLE DOSE KILLING PHARMACODYNAMICS OF ANTIMALARIAL DRUGS IN A LUCIFERASE MURINE MALARIA MODEL
(Johns Hopkins UniversityUSA, 2017-04-17)Malaria is one of the leading causes of high infant morbidity & mortality in children aged five years and below in the sub-Saharan Africa. Emergence of resistance to all classes of antimalarial drugs is currently a huge ... -
Synthetic Methodologies for Molecular Imaging: Synthesis, Cyclization and In Vitro Binding Study of Death Receptor 5 Targeted Peptides
(Johns Hopkins UniversityUSA, 2018-06-13)Molecular Imaging (MI) techniques are rapidly developed to achieve precise, early and in-time diagnosis for various disease. Unlike conventional anatomical imaging technique, non-invasive molecular imaging has paved a novel ... -
Caitlin Duckworth Vocal Pedagogy Portfolio
(Johns Hopkins UniversityUSA, 2018-05-29)The development and presentation of this Portfolio is the final project requirement for a Master of Music in Performance with an added emphasis in Pedagogy. The content includes but is not limited to: performance resume, ... -
Jennifer Ann Mayer Vocal Pedagogy Portfolio
(Johns Hopkins UniversityUSA, 2018-05-23)The development and presentation of this portfolio is the final project requirement for a Master of Music in Performance with an added emphasis in Pedagogy. The content includes but is not limited to: performance resume, ...
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